Animal models for filovirus infections  

作　　者：Vinayakumar Siragam Gary Wong Xiang-Guo Qiu 

机构地区：[1]Special Pathogens Program,Public Health Agency of Canada,Winnipeg,Manitoba R3E 3R2,Canada [2]Department of Medical Microbiology,University of Manitoba,Winnipeg,Manitoba R3E 0J9,Canada [3]Shenzhen Key Laboratory of Pathogen and Immunity,State Key Discipline of Infectious Disease,Shenzhen Third People's Hospital,Shenzhen Guangzhou 51 8020,China [4]Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Zoological Research》2018年第1期15-24,共10页动物学研究（英文）

基　　金：supported by the Public Health Agency of Canada(PHAC);partially supported by the NIH and CIHR grants to X.G.Qiu(U19 AI109762-1 and CIHR-IER-143487,respectively);the National Natural Science Foundation of China International Cooperation and Exchange Program(8161101193);National Science and Technology Major Project(2016ZX10004222)to G.Wong

摘　　要：The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates （NHPs）, causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates （NHPs）, causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.

关 键 词：FILOVIRUS Ebola virus Marburg virus Marburg virus disease Ebola virus disease Mouse-adapted ebolavirus Guinea-pig-adapted ebolavirus Sudan virus Plaque-forming units 

分 类 号：Q[生物学]