FILOVIRUS

作品数：9被引量：28H指数：3
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相关领域：医药卫生农业科学更多>>
相关期刊：《Virologica Sinica》《Biosafety and Health》《Cell Research》《Acta Pharmaceutica Sinica B》更多>>
相关基金：国家自然科学基金更多>>
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Development of a Mengla virus minigenome and comparison of its polymerase complexes with those of other filoviruses
《Virologica Sinica》2024年第3期459-468,共10页Shi-Zhe Xie Ke Yao Bei Li Cheng Peng Xing-Lou Yang Zheng-Li Shi 
supported by the Key project of the Chinese Academy of Sciences(KJZD-SW-L11 to Z.-L.S.);the Guangzhou Laboratory(SRPG22-001 to Z.-L.S.);the Advanced Customer Cultivation Project of Wuhan National Biosafety Laboratory,Chinese Academy of Sciences(2021ACCP-MS02);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0490000 to X.-L.Y.);the Young Topnotch Talent Cultivation Program of Hubei Province(X.-L.Y.);the Youth Innovation Promotion Association of the Chinese Academy of Science(X.-L.Y.).
Ebola virus(EBOV)and Marburg virus(MARV),members of the Filoviridae family,are highly pathogenic and can cause hemorrhagic fevers,significantly impacting human society.Bats are considered reservoirs of these viruses b...
关键词：Bat filovirus Mengla virus(MLAV) MINIGENOME Replication Antiviral drug screening 
Virus inoculation and treatment regimens for evaluating anti-filovirus monoclonal antibody efficacy in vivo被引量：1
《Biosafety and Health》2019年第1期6-13,共8页Logan Banadyga Zachary Schiffman Shihua He Xiangguo Qiu 
supported by the Public Health Agency of Canada。
The development of monoclonal antibodies to treat disease caused by filoviruses,particularly Ebola virus,has risen steeply in recent years thanks to several key studies demonstrating their remarkable therapeutic poten...
关键词：FILOVIRUS Ebola virus Marburg virus Monoclonal antibodies THERAPEUTICS Animal model 
Synthesis and biological evaluation of novel tricyclic matrinic derivatives as potential anti-filovirus agents被引量：2
《Acta Pharmaceutica Sinica B》2018年第4期629-638,共10页Xin Zhang Qiang Liu Qianqian Li Yinghong Li Zhandong Liu Hongbin Deng Sheng Tang Yanxiang Wang Youchun Wang Danqing Song 
supported by the National Natural Science Foundation of China (Nos. 81673307 and 81321004);CAMS Innovation Fund for Medical Sciences (2016–I2M–3–009)
Twenty-six novel tricyclic sophoridinic and matrinic derivatives containing a common chlorinated benzene fragment were designed, synthesized and evaluated for their anti-ebolavirus(EBOV)activities. Structure–activity...
关键词：Sophoridinic Matrinic Structure-activity relationship EBOV FILOVIRUS 
Type Ⅰ interferon receptor knockout mice as models for infection of highly pathogenic viruses with outbreak potential
《Zoological Research》2018年第1期3-14,共12页Gary Wong Xiang-Guo Qiu 
supported by the National Natural Science Foundation of China International Cooperation and Exchange Program(8161101193);the National Science and Technology Major Project(2016ZX10004222)to G.Wong
Due to their inability to generate a complete immune response, mice knockout for type I interferon （IFN） receptors （Ifnar-/-） are more susceptible to viral infections, and are thus commonly used for pathogenesis s...
关键词：Ifnar Mice Animal model FLAVIVIRUS FILOVIRUS ARENAVIRUS BUNYAVIRUS Henipavirus Togavirus 
Animal models for filovirus infections被引量：3
《Zoological Research》2018年第1期15-24,共10页Vinayakumar Siragam Gary Wong Xiang-Guo Qiu 
supported by the Public Health Agency of Canada(PHAC);partially supported by the NIH and CIHR grants to X.G.Qiu(U19 AI109762-1 and CIHR-IER-143487,respectively);the National Natural Science Foundation of China International Cooperation and Exchange Program(8161101193);National Science and Technology Major Project(2016ZX10004222)to G.Wong
The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates （NHPs）, causing severe hemorrhagic fevers with high fatali...
关键词：FILOVIRUS Ebola virus Marburg virus Marburg virus disease Ebola virus disease Mouse-adapted ebolavirus Guinea-pig-adapted ebolavirus Sudan virus Plaque-forming units 
Establishment of pseudovirus infection mouse models for in vivo pharmacodynamics evaluation of filovirus entry inhibitors被引量：10
《Acta Pharmaceutica Sinica B》2018年第2期200-208,共9页Qing Chen Ke Tang Xiaoyu Zhang Panpan Chen Ying Guo 
supported by grants from the National Natural Science Foundation of China (81202568, 81473256, and 81273561);the National Science and Technology Major Project (2015ZX09102-023-004);the CAMS Innovation Fund for Medical Sciences (2016-I2M-1–014);the Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study (BZ0150)
Filoviruses cause severe and fatal viral hemorrhagic fever in humans. Filovirus research has been extensive since the 2014 Ebola outbreak. Due to their high pathogenicity and mortality, live filoviruses require Biosaf...
关键词：FILOVIRUS EBOLA MARBURG PSEUDOVIRUS Entry inhibitor Mouse model 
Possible leap ahead in filovirus therapeutics被引量：5
《Cell Research》2014年第6期647-648,共2页Darrvl Falzarano Heinz Feldmann 
In a recent study published in Na ture, Warren et al describe the gen eration of a novel synthetic adenosine analogue, BCX4430, a synthetic drug like small molecule that provides protection from Ebola and Marburg viru...
关键词：病毒感染 疗法 纤维 埃博拉病毒 动物模型 类似物 小分子 合成 
Characterization of a Putative Filovirus Vaccine:Virus-Like Particles被引量：1
《Virologica Sinica》2013年第2期65-70,共6页Karen A O Martins Travis K Warren Sina Bavari 
funded by the Chemical-Biological Medical System-Joint Vaccine Acquisition Program (CBMS-JVAP) as well as the Defense Threat Reduction Agency (DTRA) (CBM.VAXV.03.11.RD.009 and A151 A.41)
Filoviruses are hemorrhagic fever viruses endemic to parts of Africa and the Philippines. Infection carries with it a mortality rate of up to 90% and currently there are no effective vaccines or therapeutics available...
关键词：FILOVIRUS EBOLA MARBURG VACCINE Virus-like particle Correlates of Protection 
Laboratory Detection and Diagnosis of Filoviruses被引量：6
《Virologica Sinica》2011年第2期73-80,共8页Yun-peng Wang Xian-en Zhang Hong-ping Wei 
Ebola virus(EBOV) and Marburg virus(MARV),belonging to the Filoviridae family,emerged four decades ago and caused severe viral hemorrhagic fever in human and other primates.As high as 50-90% mortality,filoviruses can ...
关键词：FILOVIRUS Ebola virus （EBOV） Marburg virus （MARV） Enzyme-linked immunosorbent assay（ELISA） Polymerase chain reaction （PCR） 
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