MINIGENOME

作品数：4被引量：6H指数：1
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相关领域：医药卫生更多>>
相关期刊：《Acta Pharmacologica Sinica》《Virologica Sinica》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金更多>>
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Development of a Mengla virus minigenome and comparison of its polymerase complexes with those of other filoviruses
《Virologica Sinica》2024年第3期459-468,共10页Shi-Zhe Xie Ke Yao Bei Li Cheng Peng Xing-Lou Yang Zheng-Li Shi 
supported by the Key project of the Chinese Academy of Sciences(KJZD-SW-L11 to Z.-L.S.);the Guangzhou Laboratory(SRPG22-001 to Z.-L.S.);the Advanced Customer Cultivation Project of Wuhan National Biosafety Laboratory,Chinese Academy of Sciences(2021ACCP-MS02);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0490000 to X.-L.Y.);the Young Topnotch Talent Cultivation Program of Hubei Province(X.-L.Y.);the Youth Innovation Promotion Association of the Chinese Academy of Science(X.-L.Y.).
Ebola virus(EBOV)and Marburg virus(MARV),members of the Filoviridae family,are highly pathogenic and can cause hemorrhagic fevers,significantly impacting human society.Bats are considered reservoirs of these viruses b...
关键词：Bat filovirus Mengla virus(MLAV) MINIGENOME Replication Antiviral drug screening 
Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules
《Acta Pharmacologica Sinica》2023年第7期1487-1499,共13页Yan-hong Ma Xu Hong Fang Wu Xin-feng Xu Rui Li Jin Zhong Yao-qi Zhou Shu-wen Liu Jian Zhan Wei Xu 
the National Natural Science Foundation of China(82173865,82130101);Foundation of Advanced Customer Cultivation Project of Wuhan National Biosafety Laboratory,Chinese Academy of Sciences,Shenzhen Bay Laboratory Open Fund(SZBL2021080601010);Major Program of Shenzhen Bay Laboratory(S201101001).
Ebola virus(EBOV)causes hemorrhagic fever in humans with high morbidity and fatality.Although over 45 years have passed since the first EBOV outbreak,small molecule drugs are not yet available.Ebola viral protein VP30...
关键词：EBOLA VP30 MINIGENOME high-throughput screening drug synergy 
Establishment of a Reverse Genetic System of Severe Fever with Thrombocytopenia Syndrome Virus Based on a C4 Strain被引量：6
《Virologica Sinica》2021年第5期958-967,共10页Mingyue Xu Bo Wang Fei Deng Hualin Wang Manli Wang Zhihong Hu Jia Liu 
supported by grants from the National Natural Science Foundation of China(No.31900146;Open Research Fund Program of the State Key Laboratory of Virology of China(No.2020IOV003);Team project of Health Commission of Hubei Province(WJ2019C003)。
Severe fever with thrombocytopenia syndrome virus(SFTSV)is an emerging tick-borne bunyavirus that causes hemorrhagic fever-like disease(SFTS)in humans with a case fatality rate up to 30%.To date,the molecular biology ...
关键词：BUNYAVIRUS Severe fever with thrombocytopenia syndrome virus(SFTSV) MINIGENOME Reverse genetic system T7 polymerase C4 strain 
An RNA polymerase I-driven human respiratory syncytial virus minigenome as a tool for quantifying virus titers and screening antiviral drug
《Chinese Chemical Letters》2017年第1期131-135,共5页Yuan-Hui Fu Ya-Ru Liu Yan-Peng Zheng Nan Jiang Yue-Ying-Jiao Wei Li Xiang-Lei Peng Jin-Sheng He 
supported by National Major Scientific and Technological Special Project for ‘‘AIDS and Viral Hepatitis and Other Major Infectious Diseases Prevention and Control’’ during the Twelfth Five-year Plan Period (No. 2013ZX10004-601)
Human respiratory syncytial virus（RSV） is an important pediatric pathogen of lower respiratory tract worldwide. No vaccines and antiviral drugs are available. Herein the use of an RNA polymerase I-driven RSV minigen...
关键词：Human respiratory syncytial virus Gaussia luciferase MINIGENOME Antiviral drug Drug-screening 
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