吸烟与颈动脉粥样硬化患者血清高敏C反应蛋白水平的相关性研究  

Relationship between smoking and serum hs-CRP level in carotid atherosclerosis patients

作　　者：拱忠影 杨洋 汪志云 臧大维 刘伟[2] 

机构地区：[1]天津医科大学一中心临床学院神经内科,300192 [2]天津医科大学总医院超声科

出　　处：《中华老年心脑血管病杂志》2018年第2期133-136,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：天津市卫生局科技项目(2015KZ035)

摘　　要：目的观察颈动脉粥样硬化吸烟患者血清高敏C反应蛋白(hs-CRP)变化,并分析其在不同动脉粥样硬化亚型中的差异,探讨其临床意义。方法纳入颈动脉粥样硬化的吸烟患者298例为吸烟组,颈动脉粥样硬化的非吸烟患者120例为非吸烟组,无颈动脉粥样硬化的健康吸烟者50例和非吸烟者50例分别为对照1组和对照2组。采用胶体强化免疫比浊法检测各组血清hs-CRP水平。吸烟组再按斑块是否为稳定分为稳定性斑块及不稳定性斑块,分析吸烟对颈动脉粥样硬化患者hs-CRP水平的影响。结果吸烟组血清hs-CRP水平明显高于非吸烟组[(7.26±4.24)mg/L vs(3.56±2.28)mg/L],对照1组hs-CRP水平高于对照2组[(4.34±2.74)mg/L vs(3.17±1.68)mg/L],差异有统计学意义(P<0.05)。吸烟指数与血清hs-CRP水平呈显著正相关(r=0.395,P<0.01)。不稳定性斑块患者的每日吸烟量、吸烟时间及吸烟指数明显高于稳定性斑块患者(P<0.05),高hs-CRP水平吸烟患者发生缺血及脑卒中复发事件比例显著高于低hs-CRP水平患者(11.36%vs 2.00%,P<0.01)。结论吸烟可导致颈动脉粥样硬化患者血清hs-CRP水平增高,其可能与斑块的稳定性及缺血性脑卒中的复发密切相关。Objective To study the clinical significance of serum hs-CRP level in smokers with carotid atherosclerosis （CA） and analyze its difference in subtypes of CA. Methods Two hundred and ninety-eight smokers with CA served as a smoker group and 120 non-smokers with CA served as a non-smoker group,50 healthy smokers without CA served as control group 1 and 50 healthy non-smokers served as control group 2. Their serum hs-CRP level was measured by colloid-en- hanced immunoturbidimetry. Smokers were divided into stable plaque group and unstable plaque group. Effect of smoking on serum hs-CRP level in CA patients was analyzed. Results The serum hs-CRP level was significantly higher in smoker group and control group 1 than in non-smoker group and control group 2 （7.26±4.24 mg/L vs 3.56±2.28 mg/L,4. 34±2.74 mg/L vs 3.17± 1.68 mg/L,P〈0.05）. The smoking index was positively related with the serum hs-CRP level （r=0. 395 ,P〈0.01）. The number of daily smoked cigarettes was significantly greater in unstable plaque group than in stable plaque group （P〈0.05）. The recurrence rate of ischemic stroke was significantly higher in smokers with a high serum hs-CRP level than in those with a low serum hs-CRP level （11. 36% vs 2. 00% , P〈 0. 01）. Conclusion Smoking can increase the serum hs-CRP level in CA patients,which is closely related with the stability of plaques and the recurrence of ischemic stroke.

关 键 词：颈动脉疾病 动脉粥样硬化 C反应蛋白质 吸烟 

分 类 号：R743.3[医药卫生—神经病学与精神病学]