生血宁片辅助放化疗对肺癌术后患者T淋巴细胞亚群及IL-23、IL-17水平的影响  

Influence of Shengxuening Tablets adjuvant chemotherapy on T lymphocyte subsets and IL-23 and IL-17 levels of postoperative patients with lung cancer

作　　者：朱彤[1] 饶井芬 刘承一[1] 肇爽[1] 张力[1] 

机构地区：[1]承德医学院附属医院肿瘤科,河北承德067000

出　　处：《中国医药导报》2018年第2期87-91,共5页China Medical Herald

基　　金：河北省科技支撑计划项目(20122144)

摘　　要：目的观察生血宁片辅助放化疗对肺癌术后患者T淋巴细胞亚群及白介素-23(IL-23)、白介素-17(IL-17)水平的影响。方法选取2015年10月~2017年1月承德医学院附属医院收治的肺癌术后患者92例作为研究对象,按照随机数字表法将其分为观察组和对照组,每组各46例。对照组给予同步放化疗治疗,观察组在对照组的基础上联合生血宁片治疗。治疗后,评价两组临床疗效,观察外周血象、免疫功能、IL-23、IL-17水平以及不良反应发生率。结果观察组总有效率(73.91%)显著高于对照组(52.17%),差异有统计学意义(P<0.05)。治疗后两组血小板、白细胞、中性粒细胞显著低于治疗前(P<0.05),且观察组显著低于对照组(P<0.05),两组血红蛋白治疗后与治疗前比较差异无统计学意义(P>0.05)。治疗后观察组CD3^+、CD4^+、CD8^+水平与治疗前比较差异无统计学意义(P>0.05),CD4^+/CD8^+水平显著低于治疗前(P<0.05);对照组CD3^+、CD4^+、CD4^+/CD8^+水平显著低于治疗前(P<0.05),CD8^+水平显著高于治疗前(P<0.05);观察组CD3^+、CD4^+、CD4^+/CD8^+水平显著高于对照组(P<0.05),CD8^+水平显著低于对照组(P<0.05)。治疗后两组IL-23、IL-17水平显著低于治疗前(P<0.05),且观察组显著低于对照组(P<0.05)。两组均未出现严重肝肾功能异常,两组放射性肺炎和放射性食管炎发生率比较差异无统计学意义(P>0.05),观察组胃肠道反应、骨髓抑制发生率显著低于对照组(P<0.05)。结论生血宁片辅助放化疗能够有效改善患者外周血象和T淋巴细胞亚群水平,降低IL-23、IL-17水平和不良反应发生率,提高临床疗效。Objective To observe the influence of Shengxuening Tablets adjuvant chemotherapy on T lymphocyte subsets and interleukin-23（IL-23） and interleukin-17（IL-17） levels of postoperative patients with lung cancer. Methods Ninetytwo cases of postoperative patients with lung cancer treated in Affiliated Hospital of Chengde Medical University from October 2015 to January 2017 were selected as the study objects, and they were divided into observation group and control group according to random number table method, with 46 cases in each group. The control group was given concurrent chemoradiotherapy, and the observation group was added with Shengxuening Tablets on the basis of the con trol group. After treatment, the clinical efficacy was evaluated, and the peripheral blood, immune function, levels of IL-23 and IL-17, and the incidence of adverse reactions were observed in the two groups. Results The total effective rate of the observation group（73.91%） was significantly higher than that of the control group（52.17%）（P〈0.05）. After treatment, the platelets, leukocytes, neutrophils in the two groups were significantly lower than those before treatment（P〈0.05）, and those in the observation group were significantly lower than those in the control group（P〈0.05）. There was no significant difference of hemoglobin before and after treatment（P〈0.05）. There were no significant differences of the levels of CD3^＋, CD4^＋and CD8^＋in the observation group before and after treatment（P〈0.05）, while the level of CD4^＋/CD8^＋in the observation group after treatment was significantly lower than that before treatment（P〈0.05）. After treatment, the levels of CD3^＋, CD4^＋and CD4^＋/CD8^＋in the control group were significantly lower than those before treatment（ P〈0. 05）, the level of CD8^＋wassignificantly higher than that before treatment（P〈0.05）. After treatment, the levels of CD3^＋, CD4^＋and CD4^＋/CD8^＋in the observation group were significantly higher than

关 键 词：生血宁片 放化疗 肺癌 白介素-23 临床疗效 

分 类 号：R734.2[医药卫生—肿瘤]