8Spheres微球联合碘油TACE治疗原发性肝癌的疗效及安全性  

Efficacy and Safety Analysis of 8Spheres Microspheres Combined with Lipiodol TACE in the Treatment of Hepatocellular Carcinoma

作　　者：吴宝林[1] 周军[1] 凌公豪 Anu John 龙清云[1] 

机构地区：[1]武汉大学中南医院医学影像科

出　　处：《武汉大学学报（医学版）》2018年第2期248-252,共5页Medical Journal of Wuhan University

摘　　要：目的：探讨8Spheres适形栓塞微球联合碘油肝动脉化疗栓塞（TACE）治疗原发性肝癌的近期疗效及安全性。方法：收集我院原发性肝癌患者共64例。其中试验组（8Spheres栓塞微球＋碘油栓塞）32例,对照组（单纯碘油栓塞）32例。比较两组患者介入治疗前及治疗后1周、1个月肝功能指标及甲胎蛋白（AFP）的变化。术后3个月、6个月评价两组患者肿瘤局部反应。同时比较两组患者术后并发症发生情况。结果：患者基线临床特征无统计学差异（均P〉0.05）。术后1个月两组患者肝功能均改善,但试验组肝功能指标ALT、AST和TBiL明显优于对照组（均P〈0.05）。术后1周及1个月AFP水平显著下降（均P〈0.01）,且术后1个月试验组AFP水平显著低于对照组（P〈0.01）。术后6个月试验组肿瘤客观反应率（P〈0.05）及疾病控制率（P〈0.01）均显著高于对照组,且试验组疾病进展率显著低于对照组（P〈0.01）。两组患者术后总并发症发生率无显著性差异（P〉0.05）。结论：与单纯碘油TACE相比,8Spheres栓塞微球联合碘油TACE对治疗原发性肝癌近期疗效显著,安全性较高,值得临床推广。其远期临床疗效及生存获益有待进一步随访研究。Objective： To investigate the short term efficacy and safety of transarterial chemoemboliza- tion （TACE） with 8Spheres shape-adapted embolic microspheres combined with lipiodol in the treatment of hepatocellular carcinoma （HCC）. Methods： A total of 64 patients with HCC were collected and divided into 32 cases of experimental group （8Spheres microspheresq-lipiodol） and 32 cases of control group （lipiodol）. The liver function tests and AFP levels were compared be- tween the two groups before interventional treatment, one week later, and one month later, respectively. The local tumor response of the two groups were evaluated according to the modified Response Evaluation Criteria in Solid Tumors （mRECIST） at the end of 3 and 6 months after treatment. At the same time, complications occurred after treatment were compared between the two groups. Results： There was no significant difference in baseline characteristics （P〉0.05）. Liver function improved in both of the two groups after one month of treatment. However, the indexes of alanine aminotransferase （ALT）, aspartate aminotransferase （AST） and total bilirubin （TBiL） in experimental group were all significantly better than those in control group （P〈0.05）. AFP levels decreased significantly one week and one month after treatment （both P〈 0.01）, and AFP level after one month in experimental group was significantly lower than that in control group （P〈0.01）. The objective response （OR） rate （P〈0.05） and disease control （DC） rate （P〈0.01） were significantly higher while disease progression （PD） rate （P〈0.01） was sig- nificantly lower in experimental group than those in control group at 6 the end of months after treatment. Besides, there was no significant difference in the incidence of total complications between the two groups （P〉0.05）. Conclusion： Compared with lipiodol TACE, 8Spheres embolic microspheres combined with lipiodol TACE has significant short-term efficacy and

关 键 词：肝癌 肝动脉化疗栓塞 疗效 安全性 8Spheres栓塞微球 

分 类 号：R735.7[医药卫生—肿瘤]