KLF-6在口腔扁平苔藓恶变中的表达研究  

Expression of KLF-6 in the patients with oral lichen planus canceration

作　　者：康媛媛[1] 钟鸣[2] 张英[1] 

机构地区：[1]中国医科大学口腔医学院黏膜科,辽宁沈阳110002 [2]中国医科大学口腔医学院病理科,辽宁沈阳110002

出　　处：《口腔医学》2018年第2期132-134,共3页Stomatology

摘　　要：目的探讨KLF-6在口腔扁平苔藓发病机制及癌变中的作用。方法分别采用免疫组化和Western-blot方法对10例正常口腔黏膜、30例扁平苔藓患者和22例口腔鳞癌患者的上皮组织中KLF-6蛋白进行t检测,比较其在三者之间的差异。SPSS 14.0对数据进行检验。结果扁平苔藓患者组织中KLF-6蛋白的表达明显低于正常口腔黏膜,两组之间具有显著性差异;口腔鳞癌患者组织中KLF-6蛋白的表达明显低于扁平苔藓组织,两组之间具有显著性差异。结论 KLF-6的表达异常可能在口腔扁平苔藓的发生发展及癌变的过程中起作用。Objective To examine the function of KLF-6 in the oral lichen planus pathogenesis and canceration. Methods Immu- nohistoehemistry and Western-blot were used to examine KLF-6 protein in 10 cases of normal oral mucosa, 30 cases with oral lichen planus and 22 cases with squamous cell carcinoma. SPSS 14.0 software package was used for t test. Results The expression level of KLF-6 protein in 30 cases with oral lichen planus was lower than that in 10 cases with normal oral mucosa and there was significant difference between the two groups （P〈0.05）.The expression level of KLF-6 protein in 22 cases with squamous cell carcinoma was lower than that in 30 cases with oral lichen planus.（P〈0.05） and the two groups had significant difference. Conclusions The abnormal ex- pression of KLF-6 may play a role in the development and carcinogenesis of OLP.

关 键 词：扁平苔藓 鳞癌 正常口腔黏膜 

分 类 号：R781.5[医药卫生—口腔医学]