孤立性肺结节CT灌注成像与VEGF和CD105表达的相关性研究  

Correlation between CT perfusion imaging and VEGF,and CD105 expressions in solitary pulmonary nodules

作　　者：郭俊辰 孙玲玲[1] 吴业君[1] 

机构地区：[1]中国医科大学附属第四医院放射科,沈阳110032

出　　处：《中国医师杂志》2018年第1期60-63,共4页Journal of Chinese Physician

基　　金：辽宁省自然科学基金(2013021035)~~

摘　　要：目的探讨孤立性肺结节CT灌注参数与血管内皮生长因子(VEGF)和CD105表达的相关性。方法收集成功灌注的孤立性肺结节患者48例,经手术或穿刺活检证实,其中肺癌31例,良性病变17例。比较CT灌注参数血流量(BF)、血容量(BV)、表面通透性(PS)及平均通过时间(MTT)在良恶性结节间的区别。分析肺癌CT灌注参数与VEGF和CD105表达的相关性。结果肺癌组CT灌注参数BF、BV及PS均明显高于肺部良性病变组(P<0.05),肺良恶性结节的MTT差异无统计学意义(P>0.05)。肺癌组VEGF及CD105的表达与CT灌注参数BF、BV、PS呈正相关(P<0.05),而与MTT的表达无相关性(P>0.05)。结论 CT灌注参数BF、BV及PS对鉴别孤立性肺结节的良恶性有一定帮助。肺癌组VEGF、CD105表达与BF、BV、PS呈正相关,提示CT灌注参数与肺癌血管生成有关。Objective To explore the association of CT perfusion parameters to plasma levels of vascular endothelial growth factor （VEGF） and CD105 in patients with lung cancer to provide a reference for the treatment of patients with vascular targeting anti-selection. Methods Forty eight consecutive pa- tients with diagnosed solitary pulmonary nodules underwent perfusion by 64-slice spiral CT. Among them, 31 patients were diagnosed as lung cancers and 17 diagnosed as benign lesions. Statistical methods were used to analyze the differences of CT perfusion parameters [ blood flow （BF） , blood volume （BV） , perme- ability surface （PS） , and mean transit time （MTT） ] between benign and malignant lesions, and to observe the correlation between cancer perfusion parameters and VEGF, artd CDI05. Results Compared to the group of benign lesions, the perfusion parameters BF, BV, and PS in the group of lung cancers were signifi- cantly higher than the group of benign lesions （ P 〈 0. 05 ）. MTI＇ was not different between two groups （ P 〉 0. 05）. There were positive correlations between the expressions of VEGF or CD105 and perfusion parame- ters （BF, BV, and PS） of lung cancers. There were no correlation between perfusion parameter MTT and VEGF or CD105 （P 〉 0. 05）. Conclusions CT perfusion parameters BF, BV, and PS can help in differ- entiating malignant from begin lesions. There is positive correlation between the perfusion parameters （ BF, BV, and PS） and VEGF, and CD105 of lung cancers. It indicates that CT perfusion imaging is closely re- lated to tumor angiogenesis, which may provide a non-invasive method to evaluate the blood supply.

关 键 词：硬币病变 肺/放射摄影术/代谢 体层摄影术 x线计算机 血管内皮生长因子类/代谢 血管细胞黏附分子1/代谢 

分 类 号：R734.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]