PPAR γ在子宫内膜癌中的研究进展  

Research Progress of PPAR γ in Endometrial Cancer

作　　者：黄梅梅 毛晓丹[1] 孙蓬明[1] 

机构地区：[1]福建省妇幼保健院福建医科大学附属医院,福州350001

出　　处：《国际妇产科学杂志》2018年第1期80-84,共5页Journal of International Obstetrics and Gynecology

基　　金：福建省自然科学基金(2016J01428;2017J01233)

摘　　要：过氧化氢酶增殖物激活受体(peroxisome proliferator-activated receptors,PPARs)是细胞核雌激素受体家族成员,包括PPARα、β/δ和γ。PPARγ参与脂肪与碳水化合物的代谢过程,因与多种代谢性疾病及肿瘤形成密切相关而成为研究的热点。PPARγ是配体依赖的转录因子,与子宫内膜癌细胞的增殖、侵袭和转移有关,但在子宫内膜癌中的研究较少,且具体作用机制尚不明确。综述PPARγ在子宫内膜癌相关的研究进展,旨在探讨PPARγ参与子宫内膜癌发生发展的机制,为临床后续的抗肿瘤治疗提供理论依据。Peroxisome proliferator-activated receptors(PPARs) are members of nuclear-hormone-receptor family which including PPARα, β/δ and γ. As a hotspot of researches in recent years, PPAR γ is closely related to a variety of metabolic diseases and tumors, which plays an important role in metabolism of lipid and carbohydrate. It functions as ligand-dependent transcription factors, connected with the proliferation,invasion and migration of endometrial cancer cells. The role of PPAR γ in tumorigenesis of endometrial cancer remains unclear. In this article, we reviewed studies progress of PPAR γ in endometrial cancer, discussing the role of PPAR γ in tumorigenesis of endometrial cancer and potential mechanism underlying endometrial cancer development and furthering propose theoretical basis for anti-tumor therapy.

关 键 词：PPAR γ 子宫内膜肿瘤 维甲类X受体 信号传导 过氧化氢酶增殖物激活受体-γ激动剂 

分 类 号：R737.33[医药卫生—肿瘤]