RT-PCR法检测卵巢癌中CD146表达及临床意义  

The Expression and Clinical Significance of CD146 in Ovarian Epithelial Carcinoma by RT-PCR

作　　者：周萍[1] 古力米热·乃扎尔[1] 戚婷婷[1] 袁建林[1] 

机构地区：[1]新疆医科大学附属肿瘤医院妇外三科,新疆乌鲁木齐830011

出　　处：《中国继续医学教育》2018年第3期49-51,共3页China Continuing Medical Education

基　　金：乌鲁木齐科学技术计划项目资助项目(Y141310032)

摘　　要：目的采用RT-PCR法检测卵巢上皮性癌中的CD146的表达情况,并探讨其表达与临床病理分期的相关性。方法收集30例正常卵巢组织和30例卵巢上皮性癌组织标本,采用RT-PCR技术检测CD146表达,分析CD146表达与卵巢上皮性癌临床病理分期的相关性。结果卵巢上皮性癌组织及正常卵巢组织中CD146的表达分别90%和10%,CD146表达量在卵巢癌组织中较正常组织显著升高(P<0.01),CD146在卵巢上皮性癌组织中的表达强度与病理分期有关(P<0.05)。结论 CD146的高表达与卵巢上皮性癌的发生、发展有关,可以作为卵巢癌预后及复发的特异性标记物,有可能是其诊断、术后随诊及靶向治疗的潜力分子。Objective To detect the expression of CD146 in ovarian epithelial carcinoma by RT-PCR, and to explore the correlation between its expression and clinical pathological staging. Methods 30 cases of normal ovarian tissue and 30 cases of epithelial ovarian cancer tissues were collected. The expression of CD146 was detected by RT-PCR technology, and the correlation between CD146 expression and clinicopathological stage of epithelial ovarian cancer was analyzed. Results The expression of CD146 in epithelial ovarian carcinoma and normal ovarian tissues was 90% and 10%, the expression of CD146 in ovarian cancer tissues compared with normal tissues increased significantly（P〈0.01）, CD146 in epithelial ovarian carcinoma expression and pathological stage（P〈0.05）. Conclusion The occurrence and development of cancer expression and ovarian CD146 related can be used as a specific marker of prognosis and recurrence of ovarian cancer, may be the diagnosis, postoperative follow-up and potential targeted molecular therapy.

关 键 词：CD146 卵巢癌 RT-PCR检测 临床意义 

分 类 号：R737[医药卫生—肿瘤]