喉癌组织中CD3表达的研究  

Expression of CD3 in Laryngeal Carcinoma

作　　者：李满意[1] 刘济生[1] 周慧[1] 吴文璎[1] 肖根生[1] 于亚峰[1] 

机构地区：[1]苏州大学附属第一医院耳鼻咽喉科,江苏苏州215006

出　　处：《中国继续医学教育》2018年第5期74-77,共4页China Continuing Medical Education

基　　金：江苏省苏州市科教兴卫青年科技项目(KJXW2012003)

摘　　要：目的研究CD3在喉鳞状细胞癌中的表达,探讨其临床意义。方法选择苏州大学附属第一医院2013年1月1日—2016年12月31日手术治疗的喉鳞癌50例作为喉癌组,10例正常喉组织作为对照组。免疫组化(SP法)检测CD3表达。分析此蛋白与喉鳞癌的临床病理特征之间的关系。结果 (1)喉癌组织中,CD3的阳性表达率为84.0%,高于正常对照组的20.0%,差异具有统计学意义(P<0.05)。(2)CD3与局部淋巴结转移呈负相关(r=-0.823,P<0.05),与肿瘤分区呈负相关(r=-0.831,P<0.05)、与患者性别呈负相关(r=-0.894,P<0.05),与年龄分组、T分类、病理分化程度、临床分期无明显相关性。结论(1)喉鳞状细胞癌中CD3的表达高于正常喉黏膜。(2)应用CD3检测及TNM分期、组织学分级可能会对喉鳞癌的复发、预后作出更为准确的评估。Objective To investigate the relationship between the expression of CD3 in laryngeal carcinoma and laryngeal normal mucosa. Methods 50 cases of laryngeal squamous cell carcinoma treated by surgery in the First Hospital Affiliated to Soochow University from January 1, 2013 to December 31, 2016 were selected as laryngeal cancer group, and 10 normal laryngeal tissues served as control group. The expression of CD3 was detected by immunohistochemical （SP） method. The relationship between this protein and the clinicopathological features of laryngeal squamous cell carcinoma （LSCC） was analyzed. Results （1） In laryngeal carcinoma, the positive expression rate of CD3 was 84.0%, which was higher than that of the normal control group （20.0%）, and the difference was statistically significant （P 〈 0.05）. （2） there was a negative correlation between CD3 and local lymph node metastasis （r=-0.823, P 〈 0.05）. There was a negative correlation with the region of tumor （r=-0.831, P 〈 0.05）. There was a negative correlation with the sex of the patients （r=-0.894, P 〈 0.05）. There was no significant correlation between age group, T classification, degree of pathological differentiation and clinical stage. Conclusion （1） The expressions of CD3 in laryngeal carcinoma were signifcantly higher than those in normal tissues. （2） In addition to UICC-TNM staging and pathological differentiation, they can provide more valuable clues for evaluating the recurrence and prognosis of laryngeal cancer.

关 键 词：喉癌 CD3 TNM 

分 类 号：R739[医药卫生—肿瘤]