不同运动分型帕金森病患者的非运动症状分析  

Non-motor symptoms in Parkinson′s disease patients with different motor types

作　　者：仲玲玲[1] 宋亚颀[1] 曹化[1] 居克举[1] 于亮[1] 

机构地区：[1]南京医科大学附属淮安第一医院神经内科,江苏省淮安223300

出　　处：《中华全科医师杂志》2018年第1期56-59,共4页Chinese Journal of General Practitioners

基　　金：江苏省自然科学基金（BK20141254）

摘　　要：回顾性分析2011年1月至2016年12月门诊及住院的110例帕金森病患者（PD组）的临床资料,其中73例为以姿势步态异常型（PIGD）为主、37例为以震颤型（TD）为主,以110例年龄、性别相匹配的健康者为对照组.用帕金森病非运动症状调查问卷,筛查非运动症状.PD组非运动症状总个数高于对照组[（35.2 ±3.0）与（6.0 ±2.0）个,t=6.43,P=0.01],PIGD患者总非运动症状评分高于TD患者[（28.9 ±1.1）和（6.2 ±0.7）个,t=2.73,P〈0.01],TD患者的简易精神状态检查量表和蒙特利尔认知评估量评分显著高于PIGD患者（t=11.52,P〈0.01;t=8.79,P〈0.01）.提示不同运动分型非运动症状严重程度不同,PIGD患者具有更多的非运动症状.One hundred ten patients with Parkinson′s disease（PD）and 110 age-matched healthy controls were enrolled in the study.The non-motor symptoms（NMS）were assessed with Non-motor symptoms of Parkinson′s disease questionnaire（PDNMSQ30）.The PD patients were classified as gait abnormality posture type（PIGD, n=73）and tremor type（TD, n=37）.The non-motor symptoms were compared between two groups.Results showed that the NMS in PD patients was higher than that in healthy controls[（35.2 ±3.0）vs.（6.0 ±2.0）symptoms, t=6.43, P=0.01].The NMS score of PIGD group was higher than that of TD group[（28.9 ±1.1）vs.（6.2 ±0.7）symptoms, t=2.73, P〈0.01]; Mini-mental state examination（MMSE）and Montreal cognitive assessment scale（MoCA）scores of TD group were significantly higher than those of PIGD group（t=11.52,P〈0.01; t=8.79,P〈0.01）.The results indicate that for PD patients with different motor types,their NMS are different,and PD patients with PIGD have more axial involvement,and more NMS.

关 键 词：帕金森病 运动分型 非运动症状 Hoehn-Yahr分级 震颤型 

分 类 号：R742.5[医药卫生—神经病学与精神病学]