巨噬细胞极化在脊髓损伤中的作用机制  

Mechanism of macrophage polarization on spinal cord injury

作　　者：徐保平[1,2] 姚敏[1,2] 王晓涛[1,2] 杨龙[2] 田子睿 潘艳芳[1,2] 崔学军[1,2] 

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]上海中医药大学脊柱病研究所,上海200032

出　　处：《中国骨伤》2018年第1期88-92,共5页China Journal of Orthopaedics and Traumatology

基　　金：上海市科委中医重点项目(编号:14401970400);上海市科委中医药领域中医重点项目(编号:15401972000);筋骨理论与治法教育部重点实验室(编号:教科<2009>98号);国家科技部重点领域创新团队计划项目(编号:2015RA4002)~~

摘　　要：脊髓损伤是脊柱神经系统严重的创伤,损伤后局部组织破坏和微循环障碍,引起局部损伤加重和周围神经细胞广泛坏死。脊髓损伤后常常伴随炎症反应产生各种细胞因子和生物活性物质,引起巨噬细胞极化,巨噬细胞在IFN-γ、LPS、TNF-α等刺激极化成M1巨噬细胞,主要表现为促炎和损伤作用;在IL-4、IL-10、IL-13刺激下极化为M2巨噬细胞,主要表现出抗炎和修复作用。目前脊髓损伤后的治疗手段非常有限,通过调控脊髓损伤后M1和M2巨噬细胞抑制其促炎损伤作用,促进神经修复作用是脊髓损伤后治疗的一个新方向。本文将对巨噬细胞在脊髓损伤后的极化表型及其功能特点的研究进展做一综述。Spinal cord injury is a serious trauma of the spinal and nervous system,local tissue destruction and microcirculation disturbance can lead to a more serious spinal cord injury and extensive necrosis of neurons. Spinal cord injury often accompany with Inflammation reaction producing a variety of cytokines and bioactive substances,result in macrophage polarization. M1 macrophages polarization are induced by IFN-γ,LPS,TNF-α and so on,it show the damage and proinflammatory effect. M2 macrophages polarization are caused by IL-4,IL-10,IL-13 and show the recovery and anti-inflammatory effect. However,clinical treatment after spinal cord injury is very limited,inhibition of proinflammatory and promotion of anti-inflammatory by regulating the M1 macrophages and M2 macrophages is a new direction for the treatment of spinal cord injury. The article will review different phenotype and function of macrophages after spinal cord injury.

关 键 词：脊髓损伤 巨噬细胞 综述文献 

分 类 号：R651.2[医药卫生—外科学]