黏蛋白在肺腺癌中的表达与鉴别诊断意义  

Expression of mucins and its significance of differential diagnosis in lung adenocarcinoma

作　　者：杨磊[1] 王秋苹[1] 王也[1] 杨强[1] 王蓓[1] 笪冀平[1] YANG Lei;WANG Qiu-ping;WANG Ye(Department of Pathology,China-Japan Friendship Hospital,Beijing 100029, China)

机构地区：[1]中日友好医院病理科,北京100029

出　　处：《中日友好医院学报》2018年第1期7-10,F0003,共5页Journal of China-Japan Friendship Hospital

摘　　要：目的:总结黏蛋白家族成员MUC-1、MUC-2及MUC-5AC在肺恶性肿瘤中的表达,并分析它们在病理诊断中的意义。方法:回顾性分析中日友好医院72例肺恶性肿瘤患者,其中包括黏液性腺癌22例、非黏液性腺癌29例、其它原发性肺癌8例、消化道转移癌13例。观察这些病例的MUC-1、MUC-2、MUC-5AC蛋白表达情况,并与患者临床病理信息的关系进行统计分析。结果:MUC-1在非黏液性腺癌中的表达率高于黏液性腺癌(86.2%、54.5%);MUC-5AC在黏液性腺癌中的表达率(90.9%)高于其它类型肿瘤。来源于消化道的肺转移性癌高表达MUC-2(69.2%),肺原发肿瘤则较少表达MUC-2(13.6%)。黏蛋白MUC-2、MUC-5AC与患者的肿瘤来源存在相关性(P<0.05);黏蛋白MUC-1、MUC-2、MUC-5AC的表达与年龄、性别、吸烟史、有无淋巴结转移的相关性不具有统计学意义(P>0.05)。结论:黏蛋白家族成员MUC-1、MUC-2、MUC-5AC是很好的一组生物标志物,其免疫组织化学染色对肺恶性肿瘤的诊断与鉴别诊断具有一定价值。Objective：To summerize the expressions of mucin family members MUC-1,MUC-2 and MUC-5AC in lung malignancies,and to analyze the diagnostic significance of those expressions.Methods：We retrospectively reviewed 72 cases of lung malignancies in China-Japan Friendship Hospital,including 22 cases of mucinous adenocarcinoma,29 cases of non-mucinous adenocarcinoma,8 cases of other primary lung cancer and 13 cases of metastatic carcinoma from digestive tract.The correlation between MUC-1,MUC-2 and MUC-5AC expressions and clinic pathological characteristics of those cases were analyzed.Results：Positive rate of MUC-1was higher in non-mucinous adenocarcinomas（86.2%）than in mucinous adenocarcinomas（54.4%）. MUC-5AC expression rate in mucinous adenocarcinomas（90.9%）was higher than that in other types of noeplasms.Tumors derived from digestive tracts（69.2%）expressed higher MUC-2 level than that origined from lungs（13.6%）.The expression of MUC-2 and MUC-5AC were related to tumor origin（P〈 0.05）.However,correlation between all the mucins＇ expressions and age,gender,smoking history and lymph node metastasis showed no statistical significance（all P 〉0.05）.Conclusion：MUC-1,MUC-2 and MUC-5AC are a group of effective biomarkers,their expressions by immunohistochemistry have considerable value for diagnosis and differential diagnosis of lung malignancies.

关 键 词：黏蛋白 肺肿瘤 诊断 免疫组织化学 

分 类 号：R365[医药卫生—病理学]