高龄老年病人食物不耐受与非酒精性脂肪肝关系的研究  

Study on the relationship between food intolerance and nonalcoholic fatty liver disease in elderly patients

作　　者：杨蓉 蒋毋右[1] 

机构地区：[1]上海市普陀区人民医院老年科,上海市200060

出　　处：《实用老年医学》2018年第1期43-46,共4页Practical Geriatrics

摘　　要：目的探究高龄老年病人食物不耐受情况及其与非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)的相关性。方法应用酶联免疫法检测237例高龄老年病人血清中14种食物过敏原特异性Ig G抗体,受试者按照是否患有NAFLD分成NAFLD组和非NAFLD组。结果受试者的食物不耐受总阳性率为62.03%,按Ig G抗体检测阳性率高低排序前三位的食物是:牛奶(29.11%)、鸡蛋(22.78%)、西红柿(18.99%)。NAFLD组与非NAFLD组食物不耐受发生率差异存在统计学意义(χ~2=12.749,P<0.01)。14种食物过敏原特异性Ig G抗体中,鳕鱼不耐受(χ~2=5.033,P<0.05)、鸡蛋不耐受(χ2=9.750,P<0.01)与NAFLD相关。在校正年龄、性别、甘油三酯、丙氨酸氨基转移酶和天冬氨酸氨基转移酶后,NAFLD与体质量指数(OR=1.446,95%CI:1.162~1.799)、总胆固醇(OR=2.106,95%CI:1.162~3.817)及食物不耐受(OR=9.032,95%CI:2.326~35.068)相关。结论高龄老年病人食物不耐受与NAFLD可能存在一定程度的联系。Objective To explore the correlation between food intolerance and nonalcoholic fatty liver disease（NAFLD） in elderly patients.Methods Enzyme-linked immunoassay was used to measure 14 kinds of serum specific allergic IgG antibodies in a total of 237 elderly patients,who were divided into NAFLD group and non-NAFLD group.Results In 237 participants,the total positive rate of food intolerance was 62.03%,and the leading intolerance items were milk（29.11%）,egg（22.78%）,and tomato（18.99%）.There was significant difference in the prevalence of food intolerance between NAFLD group and non-NAFLD group（χ~2= 12.749,P0.05）.Among 14 kinds of food specific allergic IgG antibodies,gadus（χ~2= 5.033,P0.05） and egg（χ^2= 9.750,P0.01） intolerance were related to NAFLD.After adjusting for age,sex,triglycerides,alanine and aspartate aminotransferase,NAFLD was positively associated with body mass index（OR = 1.446,95% CI： 1.162-1.799）,total cholesterol（OR = 2.106,95% CI： 1.162-3.817）,and food intolerance（OR = 9.032,95% CI： 2.326-35.068）.Conclusions Food intolerance might be associated with NAFLD in the elderly patients.

关 键 词：高龄老人 食物不耐受 非酒精性脂肪肝 

分 类 号：R575.2[医药卫生—消化系统]