霉菌毒素对肠道黏蛋白的影响及其作用机制  

Effects of Mycotoxins on Intestinal Mucins and Its Action Mechanism

作　　者：黄鑫 高亚男[1,2,3] 王加启[1,2,3] 郑楠[1,2,3] 

机构地区：[1]中国农业科学院北京畜牧兽医研究所,农业部奶产品质量安全风险评估实验室(北京),北京100193 [2]农业部奶及奶制品质量监督检验测试中心(北京),北京100193 [3]中国农业科学院北京畜牧兽医研究所,动物营养学国家重点实验室,北京100193

出　　处：《动物营养学报》2018年第2期476-483,共8页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金资助项目(31501399);国家重点基础研究发展计划(2011CBl00805);现代农业产业技术体系专项资金(nycytx-04-01);中国农业科学院科技创新工程(ASTIP-IASl2)

摘　　要：霉菌毒素是霉菌在谷物的田间生长阶段、收获和储藏或加工过程中产生的次生代谢产物,其广泛存在于饲料原料和人类食品中。霉菌毒素不仅会使饲料品质大大降低,而且严重损害动物的健康、降低动物生产性能,其在畜产品中的残留会给人类健康带来严重威胁。大量研究表明霉菌毒素会破坏肠道黏膜屏障,影响肠道菌群组成,改变肠道免疫应答,诱导肠道病变,引起肠道炎症等。而由肠道杯状细胞分泌的黏蛋白是肠道固有免疫第1道防线——黏液层的主要组成部分。肠道黏蛋白对维持肠黏膜动态平衡、调控微生物-宿主免疫反应起重要作用。本文结合国内外的研究,就霉菌毒素对肠道黏蛋白产生的影响及其作用机制进行综述,为今后在此领域开展更深入的研究提供理论基础。Mycotoxins are secondary metabolites produced by fungi in the field of cereal growth, harvest and storage or processing which is widely found in feed ingredients and human food. Mycotoxins not only reduce the quality of feed, but also seriously damage the health of animals, reduce animal production performance; its residues in animal products have a serious threat to human health. A large number of studies have shown that mycotoxins can damage the intestinal mucosal barrier, affecting the composition of intestinal flora, regulate in- testinal immune response, induced intestinal lesions and finally causing intestinal inflammation. The mucins se- creted by intestinal goblet cells, the main component of the mucus layer function as the intestine innate immune first defense line. Intestinal mucins play an important role in maintaining the dynamic balance of the intestinal mucosa and regulating the microbial-host immune response. The effects of mycotoxins on intestinal mucins and underlying mechanism were reviewed in this paper, which provided a theoretical basis for further researches in this field.

关 键 词：霉菌毒素 肠道黏蛋白 肠道黏膜损伤 调控机制 

分 类 号：S859.8[农业科学—临床兽医学]