综合性康复训练对脑梗死患者同型半胱氨酸水平的影响  

The effect of comprehensive rehabilitation training on homocysteine in patients with cerebral infarction

作　　者：章荣[1] 李威[1] 任凯[1] 刘佳[1] 周蜜娟[1] 

机构地区：[1]四川卫生康复职业学院附属自贡市第一人民医院康复医学科,自贡643000

出　　处：《中国康复医学杂志》2018年第2期181-186,共6页Chinese Journal of Rehabilitation Medicine

摘　　要：目的:探讨综合性康复训练对脑梗死患者血浆同型半胱氨酸水平的影响。方法:70例脑梗死患者随机分为试验组(n=35)和对照组(n=35)。两组常规药物治疗相同,试验组在此基础上配合综合性康复训练。治疗前、治疗4周和治疗8周后分别观察血浆同型半胱氨酸(Hcy)水平、临床神经功能缺损程度评分(CNDS)、临床疗效和改良Barthel指数(MBI)。结果:两组患者治疗4周和8周后,血浆Hcy水平和CNDS评分均降低,临床疗效和MBI评分均提高,与各组治疗前相比,差异均有显著性意义(P<0.05或0.01);试验组患者治疗4周和8周后,血浆Hcy水平、CNDS评分、临床疗效及MBI评分均优于对照组,差异有显著性意义(P<0.05或0.01)。结论:综合性康复训练结合常规药物治疗能够有效降低脑梗死患者血浆同型半胱氨酸水平,降低脑卒中发病的独立危险因素,改善神经功能缺损程度,提高临床疗效和日常生活活动能力,提高患者生存质量。Objective： To observe the effect of comprehensive rehabilitation training on homocysteine of patients with cerebral infarction. Method： Seventy patients with cerebral infarction were randomly divided into treatment group （n=35） and control group （n=35）. Two groups were given conventional medicine therapy. Treatment group received comprehensive rehabilitation training additionally. The level of homocysteine （Hcy）, the score of the clinical neurologic deficit scale （CNDS）, the clinical efficacy analysis and modified Barthel index （MBI） were evaluated at the beginning and at the end of the 4th and 8th week of treatment course respectively. Result： The level of Hcy and CNDS reduced and the clinical efficacy analysis and MBI increased in both groups at the end of 4th and 8th week of treatment （P〈0.05 or 0.01）; Compared with control group, the level of Hcy, CNDS, the clinical efficacy analysis and MBI in treatment group patients significantly improved at the end of 4th and 8th week of treatment （P〈0.05 or 0.01）. Conclusion： Comprehensive rehabilitation training could effectively reduce the level of Hcy of patients with cerebral infarction, reduce the risk factors of cerebral infarction, improve nerve function defect, increase the clinical efficacy analysis and activities of daily living, and improve the quality of life of patients.

关 键 词：血浆同型半胱氨酸 脑梗死患者 康复训练 神经功能缺损程度评分 改良BARTHEL指数 常规药物治疗 日常生活活动能力 水 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R493[医药卫生—临床医学]