负荷剂量瑞舒伐他汀对急性脑梗死的临床疗效及脑血流动力学的影响  

Clinical effects of loading doses of rosuvastatin in treatment of acute cerebral infarction and influence on cerebral hemodynamics

作　　者：肖静[1] 潘永霞[1] 潘成德[1] 郑宗菊[1] 谭郎敏[1] 唐坤裕 唐明山[1] 

机构地区：[1]重庆市巴南区人民医院神经内科,重庆401320

出　　处：《局解手术学杂志》2018年第2期115-119,共5页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的观察负荷剂量瑞舒伐他汀对急性脑梗死的疗效及脑血流动力学指标的影响。方法选择2014年1月至2016年6月急性脑梗死患者126例,随机分为观察组63例(负荷剂量瑞舒伐他汀,首次40 mg,以后20 mg,1次/天)与对照组63例(常规剂量瑞舒伐他汀,每次10 mg,1次/天),疗程均为3个月。比较2组治疗前、治疗1个月、3个月后的神经功能缺损(NIHSS)评分、日常生活(Barthel)指数,以及治疗3个月后的疗效与脑血流动力学指标变化。结果治疗1个月、3个月后,观察组NIHSS评分均低于对照组,差异均有统计学意义(P<0.05),观察组Barthel指数分值均高于对照组,差异均有统计学意义(P<0.05)。观察组的总有效率为88.89%,高于对照组的77.78%,但差异不具统计学意义(P>0.05)。治疗后观察组的双侧搏动指数(PI)均低于对照组,差异具有统计学意义(P<0.05),收缩期血流速度(Vs)与平均血流速度(Vm)均高于对照组,差异具有统计学意义(P<0.05),2组不良反应比较差异无统计学意义(P>0.05)。结论负荷剂量瑞舒伐他汀对急性脑梗死具有明显的治疗效果和脑血流动力学改善作用。Objective To observe the effects of loading doses of rosuvastatin in treatment of acute cerebral infarction and influence on cerebral hemodynamics. Methods One hundred and twenty-six patients of acute cerebral infarction who were admitted into hospital from January 2014 to June 2016 were selected and randomly divided into the observation group （63 cases,loading doses of rosuvastatin ,40 mg per day at the first time, and then 20 mg per day） and the control group （63 cases, routine doses of rosuvastatin, 10 mg per day）, and one course lasted for 3 months. The NIHSS scores and Barthel index before treatment, 1 month and 3 months after treatment were compared, as well as the clinical effects and cerebral hemodynamics changes 3 months after treatment. Results The NIHSS scores of the observation group at 1 month and 3 months after treatment were respectively lower than those of control group with statistical significance （ P 〈 0.05 ）, and scores of the Barthel index of the observation group were higher than those of the control group with statistical significance （ P 〈 0.05 ）. The total effective rate in the observation group was 88.89% ,which was higher than that of the control group （77.78%） ,but the difference was not statistically significant （ P 〉 0.05 ）. After the treatment, bilateral pulsation index （PI） of the observation group were lower than those of the control group （P 〈 0.05 ）. Systolic blood flow velocity （Vs） and mean blood flow velocity （Vm） were higher than those in the control group （P 〈 0.05 ）. The difference of adverse reaction between 2 groups was not statistically significant （ P 〉 0.05 ）. Conclusion Loading doses of rosuvastatin can achieve better curative efficacy in treatment of patients with acute cerebral infarction and better improvement of cerebral hemodynamics

关 键 词：脑梗死 瑞舒伐他汀 血流动力学 疗效 

分 类 号：R743[医药卫生—神经病学与精神病学]