白蛋白结合型紫杉醇单药三线治疗老年晚期非小细胞肺癌患者临床观察  

Clinical observation of nanoparticle albumin-bound paclitaxel monotherapy in the three-line treatment of elderly patients with advanced non.small cell lung cancer

作　　者：萧剑军[1] 董文静 彭杰文[1] 江小梅[1] 殷兆锋[1] 李慧芬[1] 

机构地区：[1]广东省中山市人民医院化疗科,528403

出　　处：《肿瘤研究与临床》2018年第1期57-59,共3页Cancer Research and Clinic

摘　　要：目的 观察白蛋白结合型紫杉醇（Nab-P）单药治疗老年晚期非小细胞肺癌（NSCLC）患者的临床效果和安全性.方法 回顾性分析中山市人民医院化疗科2014年1月至2017年1月使用Nab-P单药治疗的老年晚期NSCLC患者56例,年龄均≥65岁,化疗方案为Nab-P 260 mg/m2,第1天或分为第1、8天给药,每21 d为1个周期,每2个周期行影像学检查进行疗效评估.结果 56例患者均可评价疗效,均完成2个周期及以上化疗,共化疗186个周期,中位化疗周期数为3个.治疗有效率为25.0％（14/56）,疾病控制率为76.8％（43/56）,中位无进展生存时间为4.7个月.主要不良反应为中性粒细胞减少、恶心、呕吐、乏力及周围神经毒性,绝大多数患者不良反应为1～2级,经治疗后均可好转.结论 Nab-P治疗老年晚期NSCLC患者疗效肯定,不良反应轻,耐受性好,值得临床推广.Objective To evaluate the clinical efficacy and safety of nanoparticle albumin-bound paclitaxel （Nab-P） in the treatment of advanced non-small cell lung cancer （NSCLC）. Methods Fifty-six over 65 years old patients with advanced NSCLC treated with Nab-P monotherapy in department of chemotherapy of the People＇s Hospital of Zhongshan City from January 2014 to January 2017 were analyzed retrospectively. The chemotherapy regimen was Nab-P 260 mg/m2, on d1 or d1 ＋ d8, every 21 day for a cycle, imaging examination was made for efficacy evaluation after every 2 cycles. Results All 56 patients had been evaluated for efficacy, and received a total of 186 cycles of chemotherapy. All patients had been completed 2 cycles or more than 2 cycles of chemotherapy, and the median number of chemotherapy cycles was 3. The treatment response rate （RR） was 25.0 % and the disease control rate （DCR） was 76.8 %. The median progression free survival （PFS） time was 4.7 months. The main adverse reactions were neutropenia, nausea and vomiting, fatigue and peripheral nerve toxicity. However, the vast majorities of adverse reactions were grade 1-2, and can be improved after treatment. Conclusions Nab-P is effective in the treatment of advanced NSCLC in elderly patients. The adverse reactions are mild and tolerant, and it is worthy to be popularized.

关 键 词：癌 非小细胞肺 白蛋白结合型紫杉醇 药物疗法 老年人 

分 类 号：R734.2[医药卫生—肿瘤]