急性缺血性中风始发状态风证与垂体-肾上腺轴激素的关系研究  

Clinical Study on the Rleationship Between FENG Syndrome and Pituitary-adrenal Axis Hormones at the Onset of Acute Cerebral Infarction

作　　者：关少侠[1] 谌剑飞[1] 马雅玲[1] 

机构地区：[1]广州中医药大学附属珠海中医院.广东省神经内分泌重点专科,519015

出　　处：《放射免疫学杂志》2002年第4期210-211,共2页Journal of Radioimmanology

摘　　要：目的 :探讨急性缺血性中风 (急性脑梗死 ,ACI)始发状态风证与垂体 -肾上腺轴激素 (促肾上腺皮质激素ACTH、皮质醇CS)的关系。方法 :采用中风病专家经验辨证量表对 15 1例ACI患者的始发状态进行证候评分 ,同时利用放射免疫分析 (RIA)测定ACTH、CS含量 ,再按证候评分将患者分成风证组与非风证组 ,对比两组患者ACTH、CS的变化水平 ,并与健康人组 (6 0例 )作对照。结果 :①风证组的ACTH、CS水平非常显著地高于非风证组 (p <0 0 0 1) ;风证组与非风证组的ACTH、CS含量与正常健康人组比较也呈上述变化 (p <0 0 0 1) ,②77例风证组患者的风证评分与ACTH含量呈高度正相关关系 (r =0 89、t=14 6 1) ,与CS含量呈中度相关关系(r=0 5 3、t=4 83)。结论 :风证与ACTH、CS具有正相关关系 。Objective To find the relationship between FENG syndrome and pituitany-adrenal axis hormones (adrenocorticotropic hormone ACTH, corticosteroid CS) at the onsct of acute cerebral infarction (ACI). Methods Using the table of syndrome quantitative diagnosis formulated according to the experiences of apoplectic experts to score the patient at the onset for 151 cases, the patients were divided into two groups: those of FENG syndrome (score≥7 n=77) and NON-FENG syndrome (score<7 n=74). Levels of plasma ACTH and CS in there two groups and 60 healthy subject were determined with RIA. Results ①The levels of plasma ACTH and CS in the FENG group were very significantly higher than those in the NON-FENG group ( p <0 001); the same result existed between patients and healthy subjects ( p <0 001). ②Highly positive cor-relationship existed between the scores of 77 FENG syndrome cases and the levels of plasma ACTH ( r=0.89?t=14.61 ); moderately positive cor-relationship existed between the scores of FENG syndrome cases and the levels of plasma CS ( r=0 53?t=4 83 ). Conclusion There is a positive cor-relationship between FENG syndrome and pituitary adrenal axis hormones (ACTH?CS), the levels of plasma ACTH and CS can be regarded as index to differentiate FENG syndrome from NON-FENG syndrome.

关 键 词：急性缺血性中风 始发状态 风证 垂体-肾上腺轴激素 

分 类 号：R743.31[医药卫生—神经病学与精神病学]