西黄丸联合斑蝥酸钠维生素B6注射液治疗癌性发热临床研究  

Clinical observation of the effects of Xihuang pills combined with sodium cantharidinate and vitamin B6 injection in the treatment of tumor-induced fever

作　　者：刘非[1] 蒋玥[1] 杨宗宇[2] 马芹[3] 张萌[3] 张振山[1] 王国华[1] 赵恩锋[1] 

机构地区：[1]河北省沧州中西医结合医院放化疗三科,061001 [2]河北省沧州中西医结合医院骨九科,061001 [3]河北省沧州中西医结合医院放化疗四科,061001

出　　处：《国际中医中药杂志》2018年第2期116-119,共4页International Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局课题（2017278）

摘　　要：目的 评价西黄丸联合斑蝥酸钠维生素B6注射液治疗癌性发热的疗效。方法 将符合入选标准的100例癌性发热患者采用随机数字表法分为2组，每组50例。对照组给予赖氨匹林注射液治疗，治疗组给予西黄丸联合斑蝥酸钠维生素B6注射液治疗。2组均连续治疗14 d。采用ELISA法检测血清TNF-α、IL-1β；采用欧洲癌症研究与治疗组织的生命质量核心量表（European Organizationfor Research and Treatment of Cancer, Quality of Life Questionnaire-Core 30, EORTC QOL-C30）评估患者的生活质量，评价临床疗效。结果 治疗组总有效率为88.0%（44/50）、对照组为56.0%（28/50），2组比较差异有统计学意义（χ2＝12.698，P＝0.000）。治疗后，治疗组日常生活[（1.1±0.2）分比（2.5±0.2）分，t＝35.025]、与人交往[（1.2±0.1）分比（2.5±0.3）分，t＝33.124]、精神状态[（1.1±0.2）分比（2.8±0.2）分，t＝45.758]、食欲[（1.1±0.3）分比（2.6±0.2）分，t＝40.708]、睡眠[（1.2±0.2）分比（2.7±0.2）分，t＝40.139]评分均低于对照组（P＜0.01）；治疗组血清TNF-α[（1.98±0.07）mg/L比（2.86±0.13）mg/L，t＝42.144]、IL-1β[（9.20± 1.89）mg/L比（13.51±2.36）mg/L，t＝10.080]水平低于对照组（P＜0.01）。治疗期间，对照组不良反应发生率为4.0%（2/50）、治疗组为6.0%（3/50），2组比较差异无统计学意义（χ2＝0.211，P＝0.646）。结论 西黄丸联合斑蝥酸钠维生素B6注射液可降低炎性细胞因子水平，改善癌性发热患者的生活质量。Objective To study the effects of Xihuang pills combined with sodium cantharidinate and vitamin B6 injection in the treatment of tumor-induced fever. Methods A total of 100 patients with tumor-induced fever in our hospital from March 2015 to January 2017 were enrolled in this study. The subjects were divided into the control group （n=50） and the treatment group （n=50） randomly. The control group were treated with aspirin-D L-Lysine injection, and the treatment group were treated with Xihuang pills combined with sodium cantharidinate and vitamin B6 injection. The two groups were treated for 2 periods. The clinical effects of the two groups after treatment were compared. The life quality of the two groups after treatment were compared. The serum TNF-α and IL-1β of the two groups before and after treatment were compared. The adverse reaction rates of the two groups during treatment were compared. Results The total efficacy rate of defervescence of the treatment group was 88.0%（44/50） significantly higher than 56.0%（28/50） of the control group （χ2=12.698, P=0.000）. After treatment, the daily life score （1.10 ± 0.18 vs. 2.47 ± 0.21, t=35.025）, social communication score （1.21 ± 0.13 vs. 2.53 ± 0.25, t=33.124）, mental state score （1.08 ± 0.15 vs. 2.75 ± 0.21, t=45.758）, appetite score （1.13 ± 0.16 vs. 2.56 ± 0.19, t=40.708）, sleep score （1.22 ± 0.17 vs. 2.71 ± 0.20, t=40.139） of the treatment group were significantly lower than those of the control group （P〈0.05）. After treatment, the serum TNF-α （1.98 ± 0.07 mg/L vs. 2.86 ± 0.13 mg/L, t=42.144）, IL-1β （9.20 ± 1.89 mg/L vs. 13.51 ± 2.36 mg/L, t=10.080） of the treatment group were significantly lower than those of the control group （P〈0.05）. There was no significantly differences of the adverse reaction rates of the two groups during treatment （χ2=0.211, P=0.646）. Conclusions The Xihuang pills combined with sodium cantharidinate and vitamin B6 injection for patients with tumor-induced fe

关 键 词：癌性发热 西黄丸 斑蝥酸钠维生素B6注射液 生活质量 肿瘤坏死因子-α 白细胞介素-1 

分 类 号：R730.5[医药卫生—肿瘤]