丁苯酞软胶囊对帕金森痴呆患者痴呆相关因子和生活质量的影响  

Impact of butylphthalide soft capsules on the related factors and quality of life of Parkinson patients with dementia

作　　者：戴毅[1] 蔡灵钰 郑新莉 许娟[1] 吴建新[1] 吴玉泉[1] 茅安[1] 

机构地区：[1]解放军第一一七医院神经内科,浙江省杭州310013

出　　处：《中国基层医药》2018年第1期68-71,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省医学会基金项目（2013ZYC-A50）

摘　　要：目的 探究丁苯酞软胶囊对帕金森痴呆患者痴呆相关因子和生活质量的影响.方法 选择90例帕金森痴呆患者,采用随机数字表法分为研究组和对照组,每组45例.对照组采用盐酸多奈哌齐联合常规方法治疗,研究组在对照组治疗方案的基础上加用丁苯酞软胶囊治疗.检测所有患者治疗前后血清C-反应蛋白（CRP）、重组人帕金森病蛋白7（PARK7）、神经营养因子3（NT-3）的水平,采用疾病自我管理效能测量表及WHO生存质量测定量表（WHO QOL-BREF）对患者进行生活质量评价;比较两组患者治疗前后帕金森氏病综合评分量表（UPDRS）评分.结果 治疗前两组痴呆相关因子及生活质量评分、UPDRS评分差异均无统计学意义（均P ＞0.05）;治疗后两组痴呆相关因子水平均改善,但研究组改善更明显[CRP：（3.24±0.78） mg/L比（6.02±0.95） mg/L,PARK7：（13.15±1.51）μg/L比（24.93±2.02） μg/L,NT-3：（34.16±3.47） μg/L比（26.23±2.97） μg/L,均P＜0.05];治疗后研究组生活质量、UPDRS评分均较对照组改善更显著[（80.5±12.5）分比（66.0±10.3）分,（33.28±2.18）分比（41.26±2.54）分,均P＜0.05].结论 丁苯酞软胶囊能有效改善帕金森痴呆患者的痴呆相关因子,同时对患者生活质量的提高具有较好的效果.Objective To explore the impact of butylphthalide soft capsules on the related factors and quality of life of Parkinson patients with dementia.Methods 90 Parkinson patients with dementia were selected,and they were divided into the study group and the control group by the random number table method,45 cases in each group.The control group was treated with donepezil hydrochloride combined with routine nursing method,and the study group was treated with butylphthalide soft capsules based on the treatment of the control group.Before and after treatment,the serum C-reactive protein（CRP）,recombinant human Parkinson disease protein 7 （PARK7）,neurotrophic factor -3 （NT-3） levels of all patients were detected.And the quality of life of patients at admission and discharge were evaluated by the scale of disease self management efficiency and quality of life scale WHO （WHO QOL-BREF）,quality of life of the two groups was compared before and after treatment.The Parkinson＇s Disease Rating Scale （UPDRS） scores was compared between the two groups before and after treatment.Results Before treatment,the dementia related factors and quality of life score,UPDRS score of the two groups had no statistically significant differences （all P ＞ 0.05）.After treatment,the dementia related factors of the two groups were all improved,which of the study group improved significantly [CRP：（3.24 ± 0.78） mg/L vs.（6.02 ± 0.95） mg/L,PARK7：（13.15 ± 1.51） μg/L vs.（24.93 ±2.02）μg/L,NT-3：（34.16 ± 3.47） μg/L vs.（26.23 ± 2.97） μg/L,all P ＜0.05].After treatment,the quality of life（QOL） and UPDRS score of the study group were significantly higher than those of the control group [（80.5 ± 12.5） points vs.（66.0 ± 10.3） points,（33.28 ± 2.18） points vs.（41.26 ± 2.54） points,all P ＜ 0.05].Conclusion Butylphthalide soft capsules can effectively improve the dementia related factor of Parkinson patients with dementia,and enhance the quality of life with good effect.

关 键 词：痴呆 帕金森病 危险因素 生活质量 丁苯酞 

分 类 号：R749.16[医药卫生—神经病学与精神病学]