自噬在结直肠癌发生及防治中作用的研究进展  

Research Progress of Autophagy in the Development and Treatment for Colorectal Cancer Patients

作　　者：孙悦[1] 曹海龙[1] 姜葵[1] 王邦茂[1] 

机构地区：[1]天津医科大学总医院消化内科,天津300052

出　　处：《肿瘤药学》2018年第1期1-6,30,共7页Anti-Tumor Pharmacy

基　　金：国家自然科学基金(81470796;81570478)

摘　　要：自噬(autophagy)是一种进化高度保守的溶酶体依赖的自身降解途径,对于维持细胞稳态有着重要作用。这一过程与包括肿瘤在内的多种疾病有着密切联系。越来越多的证据表明自噬在结直肠癌发生发展和治疗过程中发挥着双向作用,并与其预后密切相关,可能成为潜在的防治新靶点。本文就近年来自噬与结直肠癌的相关研究进展进行了综述。Autophagy is a highly conserved lysosomal degradation pathway which contributes to maintain the intracellular homeostasis. This process is closely related to various diseases including cancer. More evidences have showed that autophagy plays a complex role in the development and therapy of colorectal cancer （CRC）, and closely related to the prognosis of CRC. The present article summarized the recent advances in the double-edged role and anti-cancer potential of autophagy for the colorectal cancer patients.

关 键 词：自噬 结直肠癌 肿瘤发生 治疗 预后 

分 类 号：R735.3[医药卫生—肿瘤]