右美托咪定对结肠癌术后胃肠功能恢复的影响  

The Effect of Dexmedetomidine on Gastrointestinal Function of Patients with Colorectal Cancer after Operation

作　　者：苑汐子[1] 党长宁[1] 孙凤伟 王永[1] 张喻然 

机构地区：[1]辽宁中医药大学附属三院肛肠五科,辽宁沈阳110000

出　　处：《肿瘤药学》2018年第1期60-63,共4页Anti-Tumor Pharmacy

摘　　要：目的探讨右美托咪定对结肠癌术后胃肠功能恢复的影响。方法选择2013年2月至2015年11月本院收治的结肠癌行手术治疗者80例,按照随机数字法分为观察组与对照组,各40例。对照组术后行常规抗感染、伤口换药、术后引流等处理,观察组在对照组基础上静脉泵入右美托咪定,持续48 h。比较干预后两组去甲肾上腺素及肾上腺素水平、胃肠功能恢复正常时间、TNF-α及hs-CRP水平以及胃肠道相关并发症。结果干预后观察组去甲肾上腺素、肾上腺素、TNF-α及hsCRP水平显著低于对照组(P<0.05),肠鸣音恢复正常时间、肛门排气时间、排便时间均早于对照组(P<0.05),肠梗阻,腹胀、腹痛及胃肠蠕动减弱的发生率显著低于对照组(P<0.05)。结论结肠癌患者术后使用右美托咪定可有效减少儿茶酚胺分泌,减轻机体炎症反应,进而促进胃肠道功能恢复,减少术后胃肠道相关并发症。Objective To investigate the effect of dexmedetomidine on postoperative gastrointestinal function recovery in colon cancer. Methods 88 patients with colorectal cancer were randomly divided into two groups： control group （n=40） and control group （n=40）. The pa-tients in control group were treated with conventional anti-infection, would dressing, postoperative drainage and other treatment, the patients in observation group were given continuous intravenous infusion of dexmedetomidine for 48 hours on the basis of treatment on control group, Gastrointestinal function returned to normal time, interventional TNF-α, hs-CRP levels, and the gastrointestinal related complications were compared between the two groups. Results The levels of norepinephrine and adrenaline in the observation group were lower than those in the control group （P〈0.05）. The levels of TNF-α and hs-CRP in the observation group were lower than those in the control group （P〈0.05）. The ratio of intestinal obstruction, bloating, abdominal pain and gastrointestinal peristalsis in the observation group were significantly higher than these of the control group （P〈0.05）. The time of defecation in the observation group was longer than that in the control group （P〈0.05）. Conclusion The use of dexmedetomidine in colorectal cancer can reduce the secretion of catechu and the inflammatory response of the body, thus promote the recovery of gastrointestinal function and reduce the complications of gastrointestinal tract.

关 键 词：右美托咪定 结肠癌 胃肠功能 

分 类 号：R735.35[医药卫生—肿瘤]