非酒精性脂肪性肝病与结直肠息肉发病的相关性分析  

Analysis of Correlation Between Nonalcoholic Fatty Liver Disease and Colorectal Polyps

作　　者：王松[1] 方放[2] 叶蕾 陈简[1] 陆恒[1] 杨妙芳[1] 汪芳裕[1] 

机构地区：[1]南京军区南京总医院消化内科,210002 [2]南京军区南京总医院干部二科,210002

出　　处：《胃肠病学》2018年第2期75-77,共3页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金(81370546);南京军区南京总医院院管课题(2017035)

摘　　要：背景:非酒精性脂肪性肝病(NAFLD)是代谢综合征的肝脏表现,其与结直肠息肉发病可能存在相关性,但仍缺乏足够的认识。目的:探讨NAFLD与结直肠息肉发病的相关性。方法:回顾性分析130例无症状体检患者的临床资料,评估NAFLD、结直肠息肉的检出率,并分析其与体重指数(BMI)、hs-CRP、三酰甘油、低密度脂蛋白、总胆固醇、丙氨酸氨基转移酶(ALT)、谷氨酰转肽酶(GGT)等的相关性。结果:与非NAFLD患者相比,NAFLD患者的结直肠息肉检出率显著升高(66.3%对40.0%,P=0.003 9),BMI、三酰甘油、ALT水平显著升高(P<0.05);而两组hsCRP、低密度脂蛋白、总胆固醇、GGT无明显差异(P>0.05)。与非结直肠息肉患者相比,结直肠息肉患者的平均年龄显著升高(P=0.013),NAFLD检出率显著升高(72.6%对47.4%,P=0.003 9),而两组BMI、hs-CRP、三酰甘油、低密度脂蛋白、总胆固醇、ALT、GGT无明显差异(P>0.05)。结论:NAFLD与结直肠息肉的发病可能密切相关。Background: Nonalcoholic fatty liver disease( NAFLD) is the liver manifestation of metabolic syndrome,and may be related with the incidence of colorectal polyps. However,studies on the correlation between NAFLD and colorectal polyps are rare. Aims: To investigate the correlation between NAFLD and colorectal polyps. Methods: Clinical data of 130 asymptomatic patients accepted physical examination were retrospectively analyzed. Detection rates of NAFLD and colorectal polyps were evaluated,and the correlations with body mass index( BMI),hs-CRP,triglyceride,low density lipoprotein,total cholesterol,alanine aminotransferase( ALT),glutamyltranspeptidase( GGT) were analyzed. Results:Compared with non-NAFLD patients,the detection rate of colorectal polyps in NAFLD patients was significantly increased( 66. 3% vs. 40. 0%,P = 0. 003 9),BMI,triglyceride and ALT were significantly increased( P < 0. 05). However,no significant differences in hs-CRP,low density lipoprotein,total cholesterol and GGT were found between NAFLD and nonNAFLD patients. Compared with non-colorectal polyps patients,the average age of patients with colorectal polyps was higher( P = 0. 013),and detection rate of NAFLD was significantly increased( 72. 6% vs. 47. 4%,P = 0. 003 9).However,no significant differences in BMI,hs-CRP,triglyceride,low density lipoprotein,total cholesterol,ALT,GGT were found between colorectal polyps group and non-colorectal polyps group( P > 0. 05). Conclusions: NAFLD may be closely correlated with the incidence of colorectal polyps.

关 键 词：非酒精性脂肪性肝病 肠息肉 回顾性研究 

分 类 号：R575[医药卫生—消化系统] R735.3[医药卫生—内科学]