结直肠息肉与尿酸、血脂水平的相关性分析  

Correlation Between Serum Uric Acid,Serum Lipids and Colorectal Polyps

作　　者：袁萍 张若尘 崔艳欣[1] 姜相君[1] 

机构地区：[1]青岛市市立医院消化内二科,266000 [2]大连医科大学

出　　处：《胃肠病学》2018年第2期98-100,共3页Chinese Journal of Gastroenterology

摘　　要：背景:结直肠息肉的临床表现无特异性,与结直肠癌的发生密切相关。目前有研究发现血尿酸、血脂水平异常与结直肠息肉发生密切相关,但仍有争议。目的:探讨尿酸、血脂水平与结直肠息肉发生的相关性。方法:选取2016年1月—2016年10月青岛市市立医院的142例结直肠息肉患者,以116例非息肉患者作为对照。检测血清UA、TG、TC、LDL-C、HDL-C水平,并分析UA与血脂的相关性。结果:与对照组相比,结直肠息肉患者TG、UA水平显著升高(P<0.05),HDL-C水平显著降低(P<0.05),TC、LDL-C水平无明显差异。结直肠息肉患者UA水平与TG、TC、LDL-C水平呈正相关(r=0.32,r=0.21,r=0.15;P<0.05),而与HDL水平呈负相关(r=-0.07,P<0.05)。结论:血清TG、UA水平增加以及HDL-C降低可能与结直肠息肉的发生相关。血清UA与TG、TC、LDL-C、HDL-C之间的相互作用可能增加结直肠息肉的发病风险。Background: Colorectal polyps( CRP) has nonspecific clinical manifestation, and is closely related to the pathogenesis of colorectal cancer. Studies have shown that abnormalities of serum uric acid( UA),serum lipids are closely related to pathogenesis of CRP,but is still in controversial. Aims: To investigate the correlation between serum UA,TG,TC,LDL-C,HDL-C and incidence of CRP. Methods: A total of 142 CRP patients from Jan. 2016 to Oct. 2016 at Qingdao Municipal Hospital were enrolled,and 116 patients without CRP were served as controls. The serum levels of UA,TG,TC,LDL-C,HDL-C were determined,and correlation between UA and serum lipids was analyzed. Results:Compared with controls,serum levels of TG,UA were significantly increased in CRP patients( P < 0. 05),HDL-C level was significantly decreased( P < 0. 05),however,no significant differences in TC,LDL-C levels were found between the two groups. Serum UA level was positively correlated to TG,TC,LDL-C levels in patients with CRP( r = 0. 32,r = 0. 21,r = 0. 15; P < 0. 05),and negatively correlated to HDL-C level( r =-0. 07,P < 0. 05). Conclusions: Increased serum TG and UA levels and decreased serum HDL-C level may be correlated to the pathogenesis of CRP. The interaction between serum UA,TG,TC,LDL-C and HDL-C may increase the risk of CRP.

关 键 词：肠息肉 尿酸 甘油三酯类 胆固醇 胆固醇 HDL 胆固醇 LDL 

分 类 号：R574[医药卫生—消化系统]