长链非编码RNA与眼的发育和疾病  

lncRNAs involved in the development and diseases of eyes

作　　者：胡丽华[1] 蒲琪 李新宇[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,中国湖北省武汉市430030

出　　处：《国际眼科杂志》2018年第3期451-456,共6页International Eye Science

基　　金：国家自然科学基金资助项目(No.81570819)~~

摘　　要：长链非编码RNA(long non-coding RNAs,lncRNAs)是长度大于200个核苷酸的非编码RNA,具有数量多、类型多、作用模式多等特点。lncRNAs生物学功能涉及基因印记、染色质重塑、mRNAs的剪切降解及翻译的调控、细胞周期调控和细胞分化调控、免疫监视,构成细胞核亚结构的骨架等,在个体发育和人类疾病中发挥着重要的作用。本文主要对目前已发现的。Long non-coding RNAs(lncRNAs) refer to a kind of non-coding RNA which is longer than 200 nucleotides,with the characteristic of its numerous,diversity of types and modes of action.The biological functions of lncRNA involved in genomic imprinting,chromatin remodeling,translational control of mRNA,cell cycle and cell differentiation control,immune surveillance,constituting the skeleton of nuclear sub structure,etc.LncRNA plays an important role in individual development and human diseases.This paper mainly reviewed those lncRNAs that have been published,and closely related to eye development and diseases.

关 键 词：长链非编码RNA 眼的发育 眼科疾病 靶基因 

分 类 号：R77[医药卫生—眼科]