PR-SET7在食管癌中表达及其临床意义  

PR-SET7 is expressed in human esophageal carcinoma and its clinical significance

作　　者：郑建[1] 陈建[1] 叶钢 

机构地区：[1]武警江苏省总队医院胸外科,江苏扬州225003

出　　处：《中国现代医学杂志》2018年第7期105-108,共4页China Journal of Modern Medicine

摘　　要：目的探讨赖氨酸甲基转移酶PR-SET7在食管癌组织中的表达及其与临床特征的相关性。方法应用免疫组织化学法检测武警江苏省总队医院2010年6月-2011年2月32例食管癌患者食管癌组织和癌旁组织中PR-SET7的表达,并探讨PR-SET7的表达量与患者性别、年龄、细胞分化程度、TNM分期及淋巴结转移等临床特征的相关性。结果 32例食管癌组织中均检测到PR-SET7的表达,癌组织中PRSET7的表达强于癌旁组织,高表达率为81.25%,癌旁组织中以弱表达为主,高表达率为15.62%(P<0.05)。PR-SET7主要表达在细胞核,食管癌中的表达与肿瘤细胞分化程度、TNM分期及淋巴结转移相关(P<0.05),与患者的性别、年龄无相关(P>0.05)。结论食管癌发生与发展过程中PR-SET7异常表达,其表达水平可能与肿瘤的进展、转移及预后密切相关。Objectgive To investigate the lysine methyltransferase （PR-SET7） expression in human esophageal cancer tissues and its correlation with clinical features. Methods The immunohistochemistry was used to detect the PR-SET7 expressions in esophageal cancer tissues and adjacent normal tissues of 32 cases at Jiangsu Armed Police General Hospital from June 2010 to February 2011. And the correlations of PR-SET7 expression with patients’ gender, age, degree of carcinoma tissue differentiation, TNM stage and lymph node metastasis were explored. Results Immunohistochemical results showed that PR-SET7 expression was found in all 32 cases of esophageal cancer tissues, and the expression of PR-SET7 in the cancerous tissues was signifcantly stronger than that of the adjacent tissues. The high-expression rate was 81.25% in theesophageal cancer tissues, the adjacent tissues chiefly had weak expression of PR-SET7 with the high-expression rate of 15.62% （P 〈 0.05）. PR-SET7 mainly expressed in the nuclei of tumor cells. PR-SET7 protein level in the patients with esophageal carcinoma was not correlated with age or sex （P 〉 0.05）, but correlated with tumor cell differentiation, TNM stage and lymph node metastasis （P 〈 0.05）. Conclusions Abnormal expression of PR-SET7 could be found in the process of oncogenesis and progression of esophageal cancer, its expression level is closely associated with tumor pregression, metastasis and prognosis.

关 键 词：PR-SET7 食管癌 表达 预后 

分 类 号：R735.1[医药卫生—肿瘤]