尼卡地平对颅脑肿瘤患者术后高血压的临床效果观察  

Efficacy of nicardipine for hypertension after surgery for brain tumors

作　　者：赵东明[1] 刘格[1] 程秋实[1] 贺彩霞[1] 王伟民[2] 

机构地区：[1]山东省青岛市市立医院干部保健二科,青岛266071 [2]山东省青岛市市立医院神经外科,青岛266071

出　　处：《中国肿瘤临床与康复》2018年第1期59-62,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨盐酸尼卡地平对颅脑肿瘤患者术后高血压的降压效果。方法选取2015年1月至2016年12月间青岛市市立医院收治的120例颅内肿瘤术后高血压患者,采用随机数表法分为A、B、C 3组,每组40例。A组患者采用硝普钠治疗,B组患者采用3μg·kg-1·min-1盐酸尼卡地平治疗,C组患者采用6μg·kg-1·min-1盐酸尼卡地平治疗。比较3组患者的临床疗效及不良反应发生情况,观察患者不同时间段的收缩压、舒张压和平均动脉压水平,并对血压降至正常值的时间进行比较。结果 A组患者临床总有效率为72.5%,B组患者为82.5%,C组患者为97.5%,3组比较,差异有统计学意义(P<0.05)。C组患者给药后5min和15min的收缩压、舒张压和平均动脉压水平均明显低于A组和B组患者,C组患者血压降至正常时间均小于A组和B组患者,差异均有统计学意义(均P<0.05)。A组患者不良反应发生率为15.0%,B组为10.0%,C组为17.5%,组间比较,差异无统计学意义(P>0.05)。结论尼卡地平治疗颅脑肿瘤患者术后高血压临床疗效显著,降压迅速,安全性高,有较高的临床应用价值。Objective To observe the efficacy of nicardipine for hypertension patients after craniotomy for brain tumors. Methods From January 2015 to December 2016,120 patients with hypertension after surgery for intracranial tumors treated at Qingdao Municipal Hospital were selected and randomly divided into group A,group B and group C using a random number table with 40 patients in each group. Patients in group A were treated with nitroprusside,patients in group B were treated with nicardipine 3 μg/kg^-1·min^-1 and patients in group C were treated with nicardipine 6 μg/kg^-1·min^-1. The clinical efficacy and adverse reactions were compared between the three groups. The systolic blood pressure,diastolic blood pressure and mean arterial pressure were observed at different times and the time when blood pressure decreased to normal were compared. Results The overall efficacy was 72. 5%,82. 5% and 97. 5% respectively for group A,group B and group C（ P〈0. 05）. The systolic pressure,diastolic pressure and mean arterial pressure were significantly lower at 5 min and 15 min after admission in group C than in group A and group B. The duration when blood pressure decreased to normal was lower in group C than in group A and group B（ P〈0. 05）.There was no significant difference in the incidence of adverse reactions among group A（ 15. 0%）,group B（ 10. 0%） and group C（ 17. 5%）（ P〉0. 05）. Conclusion The clinical efficacy of nicardipine in the treatment of postoperative hypertension in patients with brain tumors is significant,which can decrease blood pressure rapidly with high safety and great clinical value of promotion.

关 键 词：尼卡地平 硝普钠 颅脑肿瘤 高血压 

分 类 号：R739.41[医药卫生—肿瘤]