七氟醚麻醉对不同年龄结肠癌根治术患者血液流变学的影响  

Effect of sevoflurane anesthesia on hemorheology in patients of different ages undergoing radical resection for colon cancer

作　　者：王丽红[1] 全虎杰[2] 彭湃 姜万维[1] 

机构地区：[1]大连大学附属中山医院麻醉科,大连116001 [2]大连市友谊医院心血管内科,大连116001

出　　处：《中国肿瘤临床与康复》2018年第2期132-134,共3页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：大连市卫计委医学科学研究计划项目基金资助(201584)

摘　　要：目的探讨七氟醚麻醉对不同年龄结肠癌根治术患者血液流变学的影响。方法选取2015年6月至2017年6月间大连大学附属中山医院收治的90例结肠癌手术患者,按照不同年龄分为高龄组(≥60岁)和中青年组(<60岁)。患者均给予七氟醚麻醉,比较两组患者不同时间点的血液流变学指标变化。结果中青年组T1、T2、T3时间点高切变率、T3时间点低切变率、T2及T3时间点低切变率全血黏度、T1及T3时间点血浆黏度、T3时间点全血还原黏度、T2时间点红细胞刚性指数、T3时间点红细胞变形指数、T3时间点红细胞聚集指数及T1、T2、T3时间点血沉方程K值与高龄组比较,均较低,差异均有统计学意义(均P<0.05)。结论结肠癌根治术中采用七氟醚麻醉,能有效改善患者的血液流变学指标,且中青年患者的效果明显优于老年患者。Objective To explore and analyze the effects of sevoflurane anesthesia on hemorheology in patients of different ages undergoing radical resection for colon cancer. Methods From June 2015 to June 2017,90 patients undergoing surgery for colon cancer at Zhongshan Hospital Affiliated to Dalian University were selected. According to different ages,patients were divided into old group（ ≥60 years of age）and young group（ 60 years of age）. Sevoflurane anesthesia was performed on patients in both groups.Change in hemorheology indexes at different time points were compared between the two groups. Results The high shear rate at T1,T2 and T3,low shear rate at T3,viscosity of whole blood measured at low shear rates at T2 and T3,plasma viscosity at T1 and T3,reduction in whole blood viscosity at T3,erythrocyte aggregation index at T2,erythrocyte deformability index at T3,erythrocyte sedimentation at T3,equation K value of erythrocyte sedimentation rate were significantly lower in the young group than in the old group（ P〈0. 05）. Conclusion Sevoflurane anesthesia in the radical resection for colon cancer can effectively improve the hemorheology especially for young and middle-aged patients.

关 键 词：七氟醚麻醉 结肠癌根治术 不同年龄 血液流变学 

分 类 号：R735.3[医药卫生—肿瘤]