血浆置换联合血浆吸附治疗慢性肝炎黄疸的临床观察  

Clinical observation of plasma exchange combined with plasma adsorption in the treatment of chronic hepatitis with jaundice

作　　者：杜卫星 叶青 李金科 谭华炳 

机构地区：[1]湖北医药学院附属人民医院感染性疾病科,湖北十堰442000

出　　处：《中国中西医结合消化杂志》2018年第1期40-42,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：湖北省重大科学技术成果(No:EKII1062)

摘　　要：[目的]探究血浆置换联合血浆吸附治疗慢性肝炎黄疸的临床效果。[方法]选取我院收治的慢性肝炎患者100例,随机分为观察组和对照组,每组各50例。对照组患者给予综合治疗并加强护理,对照组患者在综合治疗的基础上给予血浆置换联合血浆吸附治疗。[结果]对比2组患者的肝功能指标、临床效果以及不良反应的发生率。得出结果在总有效率上,观察组达到86%,对照组达到62%,能够发现观察组比对照组明显要高(P<0.05)。在治疗前,2组患者白蛋白(ALB)、总胆固醇、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)这4项指标差异均无统计学意义(P>0.05)。治疗后,观察组的总胆固醇指标与ALB比对照组明显要高(P<0.05)。术后2组患者均无严重的不良反应,治疗后明显好转,组间比较,差异无统计学意义(P>0.05)。[结论]血浆置换联合血浆吸附治疗慢性肝炎黄疸的临床效果显著,值得推广并使用。[Objective]To explore the plasma adsorption plasmapheresis clinical effect for the treatment of chronic hepatitis with jaundice. [Methods]100 cases of patients with chronic hepatitis were selected from our hospital randomly, and equally divided into observation group and control group. The control group pa- tients were given comprehensive treatment and strengthening nursing, the observation group patients were treated basic comprehensive therapy combined plasma adsorption plasmapheresis. We compare the clinical curative effect, liver function index, the incidence of adverse reactions between these two groups. [-Results] The total effective rate of observation group patients was significantly higher than the control group, 62.00% vs. 86.00%（P〈0.05）. Before the treatment,there was no significantly difference between two groups in albumin （propagated）, total cholesterol, aspartate amino transferase （AST）, alanine aminotrans- ferase（ALT） （P〉0.05）. After treatment,the observation group of patients with propagated and total cho- lesterol levels were significantly higher than the control group, AST,ALT indexes were significantly lower than the control group（P〈0.05）. Furtherly, we found that there was no significantly difference between these two groups in serious adverse reactions（P〉0.05）. [Conclusion]Plasma exchange combined plasma adsorption could be used in the treatment of chronic hepatitis with jaundice.

关 键 词：血浆置换 血浆吸附 慢性肝炎黄疸 

分 类 号：R575.1[医药卫生—消化系统]