普芦卡必利联合高压氧治疗中老年功能性便秘的临床研究  

Clinical research on the effects of prucalopride combined with hyperbaric oxygen on middle and old- aged people with functional constipation

作　　者：乔翠霞[1] 万金娥[2] 张立泽[1] 孙晓梅[1] 赵刚[1] 

机构地区：[1]青岛大学附属医院肛肠科,山东省青岛266003 [2]青岛大学附属医院高压氧科,山东省青岛266003

出　　处：《中华航海医学与高气压医学杂志》2017年第5期370-373,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的 观察普芦卡必利联合高压氧治疗中老年功能性便秘的临床疗效,探讨其可能的作用机制.方法 352名中老年功能性便秘患者,经医院伦理委员会批准,并经患者知情同意,签署知情同意书后,通过数字表法随机分为治疗组180例和对照组172例,治疗组口服普芦卡必利片,1片/次,并配合高压氧治疗,1次/d;对照组单纯给予普芦卡必利,口服,1片/次,1次/d,疗程均为12周.记录首次治疗后24 h内出现完全自发排便（SCBM）人数、每周SCBM≥3次人数、便秘症状的改善情况及治疗后患者生活质量评分变化.结果 2组患者经治疗后：治疗组总有效率（84.4％）高于对照组（64.5％）,差异有统计学意义（P＜0.01）;治疗组治疗后24 h内出现SCBM的人数（105人）、每周SCBM≥3次人数（117人）多于对照组（68、65人）,便秘症状的改善情况优于对照组,差异均具有统计学意义（P＜0.05）;治疗后其情感职能和精神健康有明显的改善（P＜0.05）,其生理功能、生理职能及复发率与对照组比较差异无统计学意义（P＞0.05）.结论 普芦卡必利联合高压氧治疗中老年功能性便秘,能明显缓解患者的便秘症状,改善患者的精神状况,提高患者的生活质量,值得在临床上进一步推广应用.Objective To observe the effects of prucalopride combined with hyperbaric oxygen （HBO） on middle and old-aged people with functional constipation,and also to explore possible mechanism involved.Methods Three hundred and fifty-two middle and old-aged people with functional constipation were randomly divided into the treatment group （n =180） and the control group （n =172）.The treatment group was treated with prucalopride orally a pill a day combined with HBO,one session a day,with a treatment course of 12 weeks,while the control group received just prucalopride,a pill a day,also with a treatment course of 12 weeks.The number of people with complete spontaneous bowel movements （CSBM） within 24 hours after treatment,the number of people with complete spontaneous bowel movements equal or over 3 times （CSBM ≥ 3 times） per week,improvement in constipation symptoms and life quality in patients after treatment were closely observed and recorded.Results After treatment,total effective rate of the treatment group was higher than that of the control group,and statistical significance could be seen,when comparison were made between the 2 groups （P ＜ 0.01）.The number of people with CSBM within 24 hours and after treatment in the treatment group and the number of people with CSBM ≥ 3 times per week,after treatment were larger than those of the control group,and improvement in constipation symptoms was also better than that of the control group.Statistical significance could be found,when comparison were made between the 2 groups （P ＜ 0.05）.Following treatment,the emotional and mental health status were significantly improved （P ＜ 0.05）,but there were no significant differences in physiological function and recurrence rate,as compared with those of the control group （P ＞ 0.05）.Conclusions Prucalopride combined with HBO in the treatment of middle and old-aged patients with functional constipation could evidently alleviate constipation symptoms,improve their mental status and life qu

关 键 词：普芦卡必利 功能性便秘 高压氧 

分 类 号：R574.62[医药卫生—消化系统]