Synthesis of Trisubstituted Isoxazoles from Nitroenamines and Aromatic Aldehydes  

作　　者：Chao Lei Zhenhong Gao Xusheng Shao Xiaoyong Xu Zhong Li 

机构地区：[1]Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China [2]Shanghai Collaborative Innovation Center for Biomanufaeturing Technology, Shanghai 200237, China

出　　处：《Chinese Journal of Chemistry》2017年第10期1517-1521,共5页中国化学（英文版）

摘　　要：A novel approach for the synthesis of trisubstituted isoxazoles from nitroenamines and aromatic aldehydes is developed. L-Proline/potassium carbonate system was employed to promote this process. The reaction underwent nucleophilic attack of nitroenamines to aromatic aldehydes, intramolecular denitration, tautomerization and elimination of H2O to furnish the target compounds.A novel approach for the synthesis of trisubstituted isoxazoles from nitroenamines and aromatic aldehydes is developed. L-Proline/potassium carbonate system was employed to promote this process. The reaction underwent nucleophilic attack of nitroenamines to aromatic aldehydes, intramolecular denitration, tautomerization and elimination of H2O to furnish the target compounds.

关 键 词：ISOXAZOLES nitroenamines DENITRATION HETEROCYCLES synthetic methods 

分 类 号：O622.4[理学—有机化学] TS195.59[理学—化学]