Recent Developments in Azide-Free Synthesis of 1,2,3-Triazoles  

作　　者：Zhengkai Chen Gangjian Cao Jinyu Song Hongjun Ren 

机构地区：[1]Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, China

出　　处：《Chinese Journal of Chemistry》2017年第12期1797-1807,共11页中国化学（英文版）

基　　金：Acknowledgement We are grateful for the financial support from the National Natural Science Foundation of China （Grant Nos. 21602202）, the Science Foundation of Zhejiang Sci-Tech University （Grant Nos. 15062092-Y, 1206820-Y and 1206821-Y） as well as the Zhejiang Provincial Top Key Academic Discipline of Chemical Engineering and Technology of Zhejiang Sci-Tech University.

摘　　要：1,2,3-Triazoles, as one of the most significant nitrogen-containing heterocycles due to their extensive use in biology, material science and organic synthesis, have aroused great interest, 1,2,3-Triazoles are commonly synthe- sized by metal-catalyzed azide-alkyne cycloaddition and organocatalytic azide-carbonyl cycloaddition, which indispensably employ the toxic and potentially explosive azides. The azide-free synthetic approaches provide a powerful and straightforward alternative to the assembly of diverse 1,2,3-triazoles without the use of azides. In this review, we summarize the recent development of the construction of 1,2,3-triazoles under azide-free conditions.1,2,3-Triazoles, as one of the most significant nitrogen-containing heterocycles due to their extensive use in biology, material science and organic synthesis, have aroused great interest, 1,2,3-Triazoles are commonly synthe- sized by metal-catalyzed azide-alkyne cycloaddition and organocatalytic azide-carbonyl cycloaddition, which indispensably employ the toxic and potentially explosive azides. The azide-free synthetic approaches provide a powerful and straightforward alternative to the assembly of diverse 1,2,3-triazoles without the use of azides. In this review, we summarize the recent development of the construction of 1,2,3-triazoles under azide-free conditions.

关 键 词：1 2 3-triazoles azide-free HYDRAZONES diazo compounds nitrogen heterocycles 

分 类 号：V512[航空宇航科学与技术—航空宇航推进理论与工程] TS202.1[轻工技术与工程—食品科学]