Oxidative Rearrangement of Isatins with Arylamines Using H2O2 as Oxidant： A Facile Synthesis of Quinazoline-2,4-diones and Evaluation of Their Antibacterial Activity  

作　　者：Guanghao Shi Xinwei He Yongjia Shang Cheng Yang Liwei Xiang 

机构地区：[1]Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China

出　　处：《Chinese Journal of Chemistry》2017年第12期1835-1843,共9页中国化学（英文版）

基　　金：Supporting information for this article is available on the WWW under http：//dx.doi.org/10.1002/cjoc,201700280 or from the author.Acknowledgement The work was partially supported by the National Natural Science Foundation of China （No. 21172001, 21372008）, the Natural Science Foundation of Education Administration of Anhui Province （KJ2016A267）, the Special and Excellent Research Fund of Anhui Normal University and the Doctoral Scientific Research Foundation of Anhui Normal University （No. 2016XJJ110）.

摘　　要：A green and highly efficient synthetic method for the synthesis of quinazoline-2,4-diones with hydrogen peroxide as the terminal oxidant has been developed, The reaction features the mild reaction conditions, broad substrate scope, metal-free catalysts, and sole byproduct water. A plausible mechanism for this process was proposed. Moreover, an antibacterial activity study was performed to evaluate the antimicrobial activities towards two Gram-negative bacterial strains （Escherichia coli, and Klebsiella pneumonia） and two Gram-positive bacterial strains （Staphylococcus epidermidis, and Staphylococcus aureus） using the Broth microdilution method.A green and highly efficient synthetic method for the synthesis of quinazoline-2,4-diones with hydrogen peroxide as the terminal oxidant has been developed, The reaction features the mild reaction conditions, broad substrate scope, metal-free catalysts, and sole byproduct water. A plausible mechanism for this process was proposed. Moreover, an antibacterial activity study was performed to evaluate the antimicrobial activities towards two Gram-negative bacterial strains （Escherichia coli, and Klebsiella pneumonia） and two Gram-positive bacterial strains （Staphylococcus epidermidis, and Staphylococcus aureus） using the Broth microdilution method.

关 键 词：antibacterial activity hydrogen peroxide ISATINS quinazoline-2 4-diones rearrangement 

分 类 号：TS745[轻工技术与工程—制浆造纸工程] TQ432.2[化学工程]