240例乳腺癌患者化疗期间贫血相关因素分析  

Related Factors Analysis of Cancer Anemia in 240 Patients with Breast Cancer Treated by Chemotherapy

作　　者：孙世强 蔡英 邰亦成[1] 谈珂岚[1] 

机构地区：[1]江苏省常州市第一人民医院乳腺外科,213003

出　　处：《岭南急诊医学杂志》2017年第6期568-570,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:探究乳腺癌患者化疗期间癌性贫血发生相关因素,为临床化疗过程中贫血患者的早期发现及干预提供参考。方法:回顾性分析2016年1月-2017年7月本科接受手术并化疗的240例乳腺癌患者的临床资料,统计年龄、手术方式、TNM分期、化疗方案、化疗周期、化疗前Hb、高血压、糖尿病、肝功能、肾功能,并进行单因素分析及多因素Logistic分析,得出癌性贫血的独立危险因素。结果:乳腺癌患者贫血发生率随化疗周期增加呈逐渐上升趋势,第4个周期后升至最高。年龄>60岁、化疗前Hb<135 g/L、肝肾功能异常、高血压的患者,化疗后更易出现贫血,其中化疗方案、化疗前Hb、肝功能为发生癌性贫血的独立危险因素。结论:对老年女性、化疗前Hb较低、肝肾功能异常、采用紫杉烷同期化疗方案的乳腺癌患者,贫血发生率较高,需早期预防及处理。Objective：To observe the effect of chemotherapy and other risk factors on cancer anemia of tumor patients,and to provide reference for early detection and intervention of anemia patients during chemotherapy. Methods：The clinical data of 240 patients with breast cancer treated by surgery and chemotherapy from Jan 2016 to Jul 2017 were analyzed retrospectively.Univariate analysis and multivariate logistic regression analysis were performed on risk factors including age,gender,and program include age,operation mode,operation mode,TNM staging,chemotherapy regimen,chemotherapy cycle,Hb before chemotherapy,hypertension,diabetes,liver and kidney function. Results：The incidence of anemia increased gradually,and rose to the highest level after fourth cycles of chemotherapy. The occurrence of anemia was related to 6 risk factors：age60,Hb135 g/L,abnormal liver function,abnormal renal function,hypertension and chemotherapy regimen. Among them,chemotherapy regimen,Hb before chemotherapy and liver function were independent risk factors for cancer anemia. Conclusion：The incidence of anemia is higher in elderly women with lower Hb,abnormal liver function,abnormal kidney function,and chemotherapy combined with paclitaxel. Early prevention and treatment are needed.

关 键 词：乳腺癌 贫血 化疗 相关因素分析 

分 类 号：R737.9[医药卫生—肿瘤]