眼表鳞状上皮化生的研究进展  

Research progress of ocular surface squamous metaplasia

作　　者：姜楠[1] 魏荣[1] 邵毅[1] 

机构地区：[1]南昌大学第一附属医院眼科,江西330006

出　　处：《国际眼科纵览》2017年第6期405-408,共4页International Review of Ophthalmology

基　　金：国家自然科学基金（81460092、81400372、81660158）;江西省自然科学基金重大项目（2016ACB21017）;江西省青年科学基金（20151BAB215016）;江西省重点研发项目（20151BBG70223）

摘　　要：鳞状上皮化生是具有分泌功能的非角化上皮，因干眼症、热／化学伤等因素，通过Wnt信号转导通路、过氧化物酶体增生物激活物受体、p38一MAPK信号转导通路等，逐渐被无分泌功能的角化鳞状上皮所取代的病理过程。在眼表，如果不及时治疗，正常结膜上皮被无分泌功能的鳞状上皮所替代，可导致正常结膜上皮的功能丢失，引发眼表的慢性炎症，而新生血管形成又加剧了鳞状上皮化生，致使角膜溃疡甚至角膜混浊，最终导致不同程度的视力损害甚至失明。治疗以局部滴眼、抑制眼表炎性因子等为主。Squamous metaplasia is a pathological process, in which non-keratinized epithelia with secretory function gradually become non-secretory squamous epithelium. The process is usually caused by factors such as dry eyes or therma//chemical injuries through Wnt signal transduetion pathways or the peroxi- dase body biological activated receptor, p38 lightning-MAPK signal transduction pathway and so on. In the ocular surface, if not timely treatment, the normal conjunctival epithelium will be replaced by squamous epi- thelium, which may cause conjunctival epithelia loss of function and chronic inflammation of the ocular sur- face. The development of new blood vessels will aggravate squamous metaplasia, resulting in corneal ulcer and corneal opacity, eventually leading to visual impairment or even blindness. Treatment includes using local eye drops, suppressing the eye inflammation and so on.

关 键 词：鳞状上皮化生 眼表 

分 类 号：R735.2[医药卫生—肿瘤]