育龄妇女血清维生素D水平不足可能增加早期自然流产的风险  

Insufficient serum vitamin D in childbearing aged women increases risk for early miscarriage

作　　者：王立芹[1,2] 侯伟 闫晓婷[1] 惠凌云[1] 王丽[1] 白娥[1] 于学文[1] 

机构地区：[1]西安交通大学第一附属医院,陕西西安710061 [2]西安医学院护理系,陕西西安710021 [3]西北妇女儿童医院,陕西西安710002

出　　处：《中国妇幼健康研究》2017年第12期1577-1579,共3页Chinese Journal of Woman and Child Health Research

基　　金：国家自然科学基金资助项目(81270697);陕西省科技攻关资助项目(2012K17-02-06)

摘　　要：目的探讨育龄期妇女血清维生素D水平与早期自然流产的相关性,为预防早期自然流产提供理论依据和新的思路。方法收集有早期复发流产史(35例)和有正常生育史的未孕育龄妇女(35例)血清,排除已知的复发流产的因素,检测血清25羟基维生素D[(25(OH)D)]含量并进行分析。结果有早期复发流产史的未孕育龄妇女血清25(OH)D水平(13.15±8.60μg/L)明显低于有正常生育史的未孕育龄妇女(36.44±11.33μg/L)(t=9.69,P<0.05);有复发流产史的未孕育龄妇女血清25(OH)D水平不足的发生情况也明显高于有正常生育史的未孕育龄妇女(χ~2=45.73,P<0.05);Pearson相关分析显示育龄妇女血清维生素D水平不足与早期自然流产的发生明显相关(r=0.81,P<0.05)。结论有复发流产史的育龄期妇女血清维生素D水平明显降低,育龄期妇女血清维生素D不足可能增加了妊娠后早期自然流产的风险。Objective To study the association between levels of serum vitamin D and early miscarriage in childbearing aged women so as to provide theoretical basis and new thinking for preventing early miscarriage.Methods Thirty-five non-gravid cases with recurrent early miscarriage history and 35 non-gravid women with successful pregnancy history were selected.The known reasons leading to miscarriage were excluded.The serum 25-hydroxyvitamin D [25（OH）D]was measured and analyzed.Results The serum25（OH）D in non-gravid women with miscarriage history（13.15±8.60μg/L）was significantly lower than that in non-gravid women with successful pregnancy history（36.44±11.33μg/L）（t=9.69,P〈0.05）.The occurring of insufficient serum 25（OH）D in non-gravid women with miscarriage history was more severe than that in non-gravid women with successful pregnancy history（χ~2=45.73,P〈0.05）.There was a close association between low 25（OH）D levels and miscarriage history revealed by Pearson analysis（r=0.81,P〈0.05）.Conclusion Serum vitamin D level is remarkably lower in childbearing aged women with recurrent miscarriage history.Decreased serum vitamin D level in childbearing aged women may increase the risk for early miscarriage.

关 键 词：维生素D 育龄妇女 复发性早期流产 血清 

分 类 号：R153.1[医药卫生—营养与食品卫生学]