帕利哌酮缓释片、氨磺必利、奥氮平治疗首发精神分裂症患者的疗效、社会功能及服药依从性比较  

Comparison of social function,adverse reaction and medication adherence of Paliperidone,Amisulpride and Olanzapine in patients with first-episode schizophrenia

作　　者：兰智勇 胡伟明 张驰 郑利锋 高晓锋 兰吴沅 

机构地区：[1]浙江省衢州市第三医院精神科,324000

出　　处：《中国医师杂志》2018年第2期216-219,共4页Journal of Chinese Physician

基　　金：衢州市科学技术局指导性科技项目(2015098)~~

摘　　要：目的比较帕利哌酮缓释片、氨磺必利、奥氮平治疗首发精神分裂症患者的疗效、社会功能及依从性。方法选取本院2015年1月至2017年1月收治的96例首发精神分裂症作为研究对象,采用随机数字表法将患者分为三组,32例予以帕利哌酮缓释片治疗(帕利哌酮组),32例予以氨磺必利治疗(氨磺必利组),32例予以奥氮平治疗(奥氮平组),采用阳性和阴性症状评分量表(PANSS)、社会功能量表(PSP)及服药态度量表(DAI)在基线和治疗6个月末对所有患者进行评估。结果 (1)三组治疗疗效差异无统计学意义(P>0.05);(2)三组治疗后PSP、DAI评分均上升,与治疗前对比差异有统计学意义(P<0.05)。三组间对比,差异无统计学意义(P>0.05)。结论三种药物治疗首发精神分裂症疗效相当,在改善服药依从性及社会功能方面无明显差异。Objective To investigate the social function, adverse reaction and medication adher- ence of paliperidone, amisulpride, and olanzapine in patients with first episode schizophrenia. Methods A total of 96 patients with first episode of schizophrenia was randomly divided into three groups, with reference to random numbers, among which there were 32 in paliperidone group, 32 cases in amisulpride group, and 32 in olanzapine group. All the patients in all groups were assessed with negative and positive scale （ PAN- SS）, personal and social performance scale （PSP） , drug attitude inventol-y （DAI） at baseline and the end of 6 months. Results （1） There was no significant difference in the therapeutic effect between three groups （ P 〉 0. 05 ） ; （2） The scores of PSP and DAI were increased in three groups after treatment, and the difference was statistically significant compared to that before treatment （ P 〈 0.05 ）. Conclusions Three drugs have similar efficacy in the treatment of first-episode schizophrenia, and there is no significant difference in improving medication compliance and social function.

关 键 词：抗精神病药/治疗应用 异恶唑类/类似物和衍生物 异恶唑类/治疗应用 苯二氮I ZHUO I类/治疗应用 精神分裂症/药物疗法 治疗结果 

分 类 号：R749.3[医药卫生—神经病学与精神病学]