埃索美拉唑与莫沙必利联用对反流性食管炎患者的影响  

Effect of esomeprazole combined with mosapride on treating patients with reflux esophagitis

作　　者：蒋建梅[1] 

机构地区：[1]江苏省淮安市洪泽县人民医院,江苏淮安223100

出　　处：《实用临床医药杂志》2018年第5期108-110,共3页Journal of Clinical Medicine in Practice

摘　　要：目的研究反流性食管炎患者采取埃索美拉唑与莫沙必利联合治疗的疗效。方法选择本院200例反流性食管炎患者作为研究对象,根据治疗方法不同分为2组,对照组80例采取莫沙必利联合奥美拉唑治疗,研究组120例则采取莫沙必利联合埃索美拉唑治疗。观察2组患者临床效果、不良反应,以及治疗前后典型症状反酸与烧心积分、生活质量评分。结果研究组总有效率显著高于对照组(P<0.05);研究组不良反应发生率明显低于对照组(P<0.05);2组患者治疗前典型症状反酸与烧心积分比较差异无统计学意义(P>0.05),但治疗后研究组以上积分明显低于对照组(P<0.05);2组患者治疗前生活质量评分比较差异无统计学意义(P>0.05),治疗后研究组明显高于对照组(P<0.05)。结论反流性食管炎患者采取埃索美拉唑联合莫沙必利治疗不仅可以提高临床效果,而且可以更好地改善症状,提高患者的生活质量,且不良反应少,安全性高,值得借鉴。Objective To study effect of esomeprazole combined with mosapride for patients with reflux esophagitis. Methods A total of 200 patients with reflux esophagitis in our hospital were divided into two groups according to different treatment methods. The control group （n=80 ） took mosapride combined with omeprazole for treatment, while the study group （n = 120） took esome- prazole combined with mosapride for treatment. Clinical effect, adverse reaction, and acid reflux and heartburn scores before and after treatment, life quality score of two groups were observed. Results The study group had higher total efficiency （ P 〈 0.05 ） , and lower incidence of adverse reactions than the control group （P 〈 0.05 ）. Before treatment, typical symptoms including heartburn and acid re- flux had no significant differences （P 〉 0.05 ） , but study group was lower than the control group in above indicators（ P 〈0.05 ） ; Before treatment, quality of life scores have no significant difference in two groups （ P 〉 0.05 ）, but the study group after treatment was significantly higher than the control group （ P 〈 0.05 ）. Conclusion Esomeprazole combined with mosapride treatment not only can im- prove the clinical effect, and enhance clinical symptoms and quality of life scores, but can reduce adverse reactions and improve safety, so it is worthy of promotion.

关 键 词：反流性食管炎 莫沙必利 埃索美拉唑 生活质量 

分 类 号：R571[医药卫生—消化系统]