泛素化在肿瘤治疗方面的应用及展望  

Applications and prospects of ubiquitin in oncotherapy

作　　者：王佳悦 赵博[1] 

机构地区：[1]上海交通大学药学院,上海200240

出　　处：《生命的化学》2017年第6期879-887,共9页Chemistry of Life

基　　金：985高校专项基金项目(WF114117001/004;WF220417001);国家自然科学基金项目(31770921)

摘　　要：泛素化是指包括泛素分子、泛素活化酶、泛素结合酶、泛素连接酶及蛋白酶体在内的多步级联的蛋白质修饰过程,是维持真核细胞内稳态的重要机制。肿瘤的发生多与肿瘤抑制因子和肿瘤蛋白间的平衡被破坏有关,而这一异常与泛素化途径紧密相连。本文重点综述了近年来泛素化在肿瘤治疗方面的应用进展及前景。Ubiquitination is a multistep protein modification process by ubiquitin, ubiquitin-activating enzyme, conjugating enzyme, ligase and proteasome, which is vital in maintaining homeostasis in eukaryotic cells. Tumorigenesis usually happens when the balance between oncoprotein and tumor suppressor is disturbed, which is closely related to ubiquitination. This article mainly reviews studies about ubiquitination with its applications and prospects in oncotherapy in recent years.

关 键 词：泛素化 泛素连接酶 蛋白酶体 肿瘤治疗 

分 类 号：R730.5[医药卫生—肿瘤]