进展期胃癌患者的VEGF-C蛋白表达情况及其临床意义分析  

VEGF-C protein expression and its clinical significance in patients with advanced gastric cancer

作　　者：樊振军 邹亚君 郑文龙 

机构地区：[1]复旦大学附属浦东医院消化内科,上海201300 [2]复旦大学附属浦东医院全科医学科,上海201300 [3]复旦大学附属浦东医院检验科,上海201300

出　　处：《癌症进展》2017年第12期1420-1422,共3页Oncology Progress

摘　　要：目的探讨进展期胃癌患者血管内皮生长因子-C(VEGF-C)的表达情况及其临床意义。方法选取80例进展期胃癌患者为胃癌组,同期80例胃炎患者为胃炎组。观察两组患者的VEGF-C蛋白表达情况,比较不同临床病理特征进展期胃癌患者的VEGF-C表达情况,分析影响进展期胃癌患者VEGF-C表达情况的因素。结果胃癌组患者的VEGF-C阳性表达率为81.25%,明显高于胃炎组的7.50%(P﹤0.01)。肿瘤直径≥5 cm、有脉管浸润和癌胚抗原(CEA)水平异常的进展期胃癌患者的VEGF-C阳性表达率明显高于肿瘤直径﹤5 cm、无脉管浸润和CEA水平正常的患者,差异均有统计学意义(P﹤0.01);不同年龄、性别和肿瘤部位的进展期胃癌患者的VEGF-C阳性表达率比较,差异均无统计学意义(P﹥0.05)。Logistic回归分析结果显示,肿瘤直径≥5 cm和脉管浸润是进展期胃癌患者VEGF-C阳性表达率高的危险因素(P﹤0.05)。结论进展期胃癌患者的VEGF-C阳性表达率较高,且肿瘤直径≥5 cm、有脉管浸润的患者VEGF-C阳性表达率更高,可作为临床判断进展期胃癌的重要指标。Objective To investigate the expression level of vascular epithelial growth factor-C（VEGF-C） in patients with advanced gastric cancer and to analyze its clinical significance. Method 80 patients with advanced gastric cancer were included as the gastric cancer group, while another 80 gastritis patients were enrolled as control group. The level of VEGF-C protein expression in the two groups were observed, and the VEGF-C levels in advanced gastric cancer patients with different clinicopathological features were compared, and the factors influencing the level of VEGF-C in patients with advanced gastric cancer were analyzed. Result The positive rate of VEGF-C in gastric cancer group was 81.25%,which was significantly higher than that in gastritis group at 7.50%（P〈0.01）; tumor diameter ≥5 cm, presence of vascular invasion and abnormal carcino-embryonic antigen（CEA） level were associated with higher positive expression rate of VEGF-C in gastric cancer patients as compared with those with tumor diameter 5 cm, no vascular invasion and normal CEA level, the difference was of statistically significance（P〈0.01）; while there was no significant difference in regard of the rate of positive expression of VEGF-C in advanced gastric cancer patients with different age, gender or tumor location（P〈0.05）. Logistic regression analysis showed that, tumor diameter ≥5 cm and presence of vascular invasion are risk factors of high positive expression of VEGF-C in gastric cancer patients（P〈0.05）. Conclusion Patients with advanced gastric carcinoma have high positive expression of VEGF-C protein, besides, tumor diameter ≥5 cm and vascular invasion are associated with higher expression of VEGF-C protein, which may be applied as an important index for the clinical judgment of advanced gastric cancer.

关 键 词：胃癌 VEGF-C 分化 临床病理特征 

分 类 号：R735.2[医药卫生—肿瘤]