非侵袭性远端肢体缺血后适应对后循环缺血功能恢复的影响  

Effects of non-invasive remote limb ischemic postconditioning on the neurological function recovery of posterior circulation ischemia

作　　者：阚培林[1] 李晓燕 孙静[1] 杨小娟 张晓霏 陈艳[1] 胡彦红 申晓琳 杨海燕 王玉[2] 

机构地区：[1]新疆生产建设兵团第二师库尔勒医院神经内科,841000 [2]安徽医科大学第一附属医院神经内科

出　　处：《临床神经病学杂志》2018年第1期19-22,共4页Journal of Clinical Neurology

摘　　要：目的探讨非侵袭性远端肢体缺血后适应(NRLIP)对后循环缺血功能恢复的影响。方法将160例后循环缺血眩晕患者随机分为NRLIP组(80例)和对照组(80例)。入组患者给予常规内科治疗,NRLIP组加用NRLIP。采用欧洲头晕评估量表(EEV)评价入院时及入院治疗7 d后的神经功能,同时检测患者血清超敏C-反应蛋白(hs-CRP)、纤维蛋白原(FIB)、D-二聚体(D-D)及血糖(FPG)水平。结果 NRLIP组治疗第7 d EEV评分及hs-CRP、D-D、FIB水平显著低于入院时(均P<0.05),空腹GLU水平差异无统计学意义(P>0.05);对照组治疗第7 d时EEV评分显著低于入院时(P<0.01),hs-CRP、D-D、FIB、FPG水平差异无统计学意义(均P>0.05)。NRLIP组及对照组入院时EEV评分及hs-CRP、D-D、FIB、FPG水平差异无统计学意义(均P>0.05)。与对照组比较,NRLIP组治疗第7 d时hs-CRP水平显著降低,NRLIP组EEV评分、hs-CRP及FIB水平差值显著升高(均P<0.01),EEV评分、D-D水平、FIB水平、FPG水平、D-D水平差值、FPG水平差值差异无统计学意义(均P>0.05)。患者均无明显不良反应。结论 NRLIP对后循环缺血患者神经功能改善起到一定的促进作用。Objective To explore the effects of non-invasive remote limb ischemic postconditioning （NRLIP） on the neurological function recovery of posterior circulation ischemia （PCI）. Methods One hundred and sixty PCI patients with vertigo were randomly divided into NRLIP group （80 cases） and control group （80 cases ）. All the patients accepted regular treatment and NRLIP group patients treated with NRLIP besides regular treatment. European evaluation of vertigo （EEV） scale was employed to assess the neurological function at the time of admission and at 7 d after admission. And the levels of serum high sensitivity C-reactive protein （ hs-CRP）, fibrinogen （ FIB）, D- dipolymer （D-D） and fasting plasma glucose （FPG） were measured. Results EEV value and the levels of hs-CRP, D-D and FIB in NRLIP group at 7 d after treatment were significantly decreased than those at admission （all P 〈 0. 05 ）, and there was no statistical significance in FPG level （ P 〉 0. 05 ）. EEV value in control group at 7 d after treatment were significantly decreased than that at admission （ P 〈 0. 01 ）, there was no statistical significance in hs- CRP, D-D, FIB, FPG levels （ all P 〉 0. 05）. EEV value and the levels of hs-CRP, D-D, FIB and FPG at admission had no statistical significance between NRLIP group and control group （ all P 〉 0.05 ）. Compared with control group, hs-CRP level in NRLIP group at 7 d after treatment was significantly decreased （ P 〈 O. 01 ）, the difference value of EEV and FIB in NRLIP group were significantly increased （ all P 〈0. 01 ）, and D-D level, hs-CRP level, FIB level and FPG level and difference value of D-D and FPG had no statistical significance （ all P 〉 0. 05 ）. No obvious adverse effect was observed on all patients. Conclusion NRLIP has a facilitating effect on the neurological functional recovery of PCI.

关 键 词：脑血管疾病 后循环缺血 非侵袭性远端肢体缺血 缺血后适应 

分 类 号：R743[医药卫生—神经病学与精神病学]