血清白介素-18及社会心理因素与急性脑梗死后抑郁的关系  

Relationship of serum interleukin-18 level,psychosocial factors and depression after acute cerebra linfarction

作　　者：费鹏鸽[1] 张朝辉[1] 宋景贵[2] 杜爱玲[1] 张留莎[1] 

机构地区：[1]新乡医学院第二附属医院神经内科,453002 [2]新乡医学院第一附属医院神经内科

出　　处：《临床神经病学杂志》2018年第1期64-66,共3页Journal of Clinical Neurology

基　　金：国家自然科学基金资助项目(81471349)

摘　　要：目的探讨血清IL-18及社会心理因素与急性脑梗死后抑郁的关系。方法采用社会支持量表(SSRS)评价31例急性脑梗死后抑郁患者(抑郁组)及36例无抑郁患者(无抑郁组)的社会心理因素,应用ELISA法检测血清IL-18水平。结果与非抑郁组比较,抑郁组入院时血清IL-18水平差异无统计学意义(P>0.05),第2周血清IL-18水平显著升高(t=4.243,P=0.000)。抑郁组第2周血清IL-18水平显著高于入院时(t=-3.169,P=0.004),非抑郁组治疗前后差异无统计学意义(t=1.246,P=0.221)。抑郁组SSRS总分、主观支持及支持利用度评分显著低于非抑郁组(t=-3.342,P=0.001;t=-2.416,P=0.018;t=-3.771,P=0.000)。结论急性脑梗死后抑郁患者血清IL-18水平、社会支持、主观支持、支持利用度可能在急性缺血性卒中患者抑郁发生中起重要作用。Objective To investigate relationship of serum IL-8 level, psychosocial factors and depression after acute cerebral infarction （ACI）. Methods Psychological factors of 31 patients with depression after ACI （depression group） and 36 patients with no depression （no depression group） were evaluated by social support scale （SSRS）. Serum IL-18 level was measured by ELISA. Results Compared with no depression group, serum IL-18 level in depression group on admission had no significant difference （P〉 0. 05 ）, and serum IL-18 level was significantly higher at 2nd week （t =4. 243, P =0. 000）. The level of serum IL-18 at 2nd week was significantly higher than that at admission in depression group （ t = - 3. 169, P = 0. 004）, and non-depression group had no statistical significance （t = 1. 246, P = 0. 221 ）. The SSRS score, subjective support score and support utilization score in depression group were significantly lower than those in non-depression group （ t = - 3. 342, P = 0. 001 ; t = -2.416,P=0.018; t= -3.771, P=0.000）. Conclusion Serum IL-18 level, social support, subjective support and support utilization may play important roles in depression after ACI.

关 键 词：急性脑梗死 抑郁 IL-18 社会支持量表 

分 类 号：R743[医药卫生—神经病学与精神病学]