乳腺癌实验动物模型的研究进展  

Research progress in experimental animal models of breast cancer

作　　者：李日飞[1] 袁娜 冶冬阳[1,3] 李日勇 李姚涵 左儒楠 时晰 陈强 李引乾[1] 

机构地区：[1]西北农林科技大学动物医学院,陕西杨凌712100 [2]徐州医科大学,听觉与平衡医学研究所,江苏徐州221004 [3]江苏沿海地区农业科学研究所,江苏盐城224002 [4]北京大学医学部,北京100191

出　　处：《中国比较医学杂志》2018年第2期113-118,共6页Chinese Journal of Comparative Medicine

基　　金：江苏省大学生创新创业基金(16621632,KYLX14-1455,201610313002Z)

摘　　要：乳腺癌是女性最常见的自发性恶性肿瘤,给女性健康造成了严重威胁。而对乳腺癌的相关研究及治疗方法的探索上,在一定程度上需要依赖于乳腺癌实验动物模型得以实现。理想的乳腺癌实验动物模型应与人类乳腺癌在肿瘤分子特性及生物学行为等方面存在共性,以便于研究各种乳腺癌的发病机制及治疗新药的开发。本文对5种乳腺癌实验动物模型的研究进展进行了综述,以期为人乳腺癌的诊断和治疗提供依据。Breast cancer is the most common spontaneous malignancy in women,causing a serious threat to women＇s health. Experimental animal models have been important research tools in bringing insights into the related mechanisms of breast cancer,as well as in delivering improved therapies for the disease. To reveal the pathogenesis of various breast cancers and facilitate the development of new drugs,ideal animal models of breast cancer should share some common tumor molecular characteristics and biological behavior with that of human breast cancer. In this review,five types of experimental animal breast cancer models were included,which may provide a basis for research on diagnosis and treatment of human breast cancer.

关 键 词：乳腺癌 实验动物模型 研究进展 

分 类 号：R-33[医药卫生]