A Fiber Tractography Study of Social-Emotional Related Fiber Tracts in Children and Adolescents with Autism Spectrum Disorder  

作　　者：Yun Li Hui Fang Wenming Zheng Lu Qian Yunhua Xiao Qiaorong Wu Chen Chang Chaoyong Xiao Kangkang Chu Xiaoyan Ke 

机构地区：[1]Nanjing Brain Hospital Affiliated to Nanjing Medical University,Child Mental Health Research Center [2]Key Laboratory of Child Development and Learning Science of the Ministry of Education, Research Center for Learning Science, Southeast University

出　　处：《Neuroscience Bulletin》2017年第6期722-730,共9页神经科学通报（英文版）

基　　金：supported by The National Key Research and Development Program of China (2016YFC1306200);the National Natural Science Foundation of China (91132750);Major Projects of the National Social Science Foundation of China (14ZDB161);the Key Research and Development Program of Jiangsu Province, China (BE2016616)

摘　　要：The symptoms of autism spectrum disorder（ASD） have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the‘‘disconnectivity＇＇ hypothesis has been used to explain characteristic impairments in ‘‘socio-emotional＇＇ function.Therefore, in this study we compared the facial emotional recognition（FER） feature and the integrity of socialemotional-related white-matter tracts between children and adolescents with high-functioning ASD（HFA） and their typically developing（TD） counterparts. The correlation between the two factors was explored to find out if impairment of the white-matter tracts is the neural basis of social-emotional disorders. Compared with the TD group,FER was significantly impaired and the fractional anisotropy value of the right cingulate fasciculus was increased in the HFA group（P ／ 0.01）. In conclusion, the FER function of children and adolescents with HFA was impaired and the microstructure of the cingulate fasciculus had abnormalities.The symptoms of autism spectrum disorder（ASD） have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the‘‘disconnectivity＇＇ hypothesis has been used to explain characteristic impairments in ‘‘socio-emotional＇＇ function.Therefore, in this study we compared the facial emotional recognition（FER） feature and the integrity of socialemotional-related white-matter tracts between children and adolescents with high-functioning ASD（HFA） and their typically developing（TD） counterparts. The correlation between the two factors was explored to find out if impairment of the white-matter tracts is the neural basis of social-emotional disorders. Compared with the TD group,FER was significantly impaired and the fractional anisotropy value of the right cingulate fasciculus was increased in the HFA group（P ／ 0.01）. In conclusion, the FER function of children and adolescents with HFA was impaired and the microstructure of the cingulate fasciculus had abnormalities.

关 键 词：Autism spectrum disorder Facial emotional recognition Social-emotional related white matter fiber tracts Diffusion tensor imaging Tractography 

分 类 号：R749.94[医药卫生—神经病学与精神病学]