反射式共聚焦显微镜在不典型脂溢性角化病诊断中的应用  

The application of reflectance confocal microscopy in the diagnosis of atypical seborrheic keratosis

作　　者：张晓燕[1] 马杰[1] 吕永靖 赵晨光[1] 杨雪萍[1] 赵建斌[1] 

机构地区：[1]徐州市第一人民医院皮肤科,221002

出　　处：《实用皮肤病学杂志》2017年第6期324-327,共4页Journal of Practical Dermatology

基　　金：徐州市自然基金(KC16SH088)

摘　　要：目的探讨反射式共聚焦显微镜(reflectance confocal microscopy,RCM)在不典型脂溢性角化病中的临床应用。方法用RCM观察临床表现不典型的5例脂溢性角化病患者。结果 5例脂溢性角化病患者虽然临床表现不典型,但其皮肤RCM检测均能发现其共同的且具有特异性的组织病理学改变,包括表皮乳头瘤样增生,呈脑回样结构,可见假性角囊肿形成等,从而辅助临床诊断。结论 RCM作为一种新的无创性皮肤科检查方法,有助于不典型脂溢性角化病的诊断和鉴别诊断。Objective To investigate the clinical application of reflectance confocal microscopy in the diagnosis of atypical seborrheic keratosis. Methods Five patients with atypical seborrheic keratosis were observed by reflectance confocal microscopy（RCM）. Results Although the clinical manifestations of the 5 patients were atypical, some common and characteristic pathological changes were found by RCM detection in the all 5 patients, including papillomatous hyperplasia, gyriform structure and pseudohorn cyst, which may help the doctor make a correct diagnosis. Conclusion As a novel non-invasive dermatologic examination method, RCM may be helpful for the diagnosis and differential diagnosis of atypical seborrheic keratosis.

关 键 词：反射式共聚焦显微镜 脂溢性角化病 诊断 

分 类 号：R739.5[医药卫生—肿瘤]