伽玛刀照射兔三叉神经后TSEP变化的实验研究  

Gamma knife irradiation-induced trigeminal somatosensory evoked potentials changes in trigeminal nerves of rabbits

作　　者：程轶峰[1] 刘东[1] 徐德生[1] 宗永青[1] 戈有林[1] Cheng Yifeng;Liu Dong;Xu Desheng;Zong Yongqing;Ge Youlin(Gamma Knife Center, Department of Neurosurgery, Second Hospital of Tianjin Medical University, Tianjin 300211, China)

机构地区：[1]天津医科大学第二医院神经外科伽玛刀中心,天津300211

出　　处：《中华神经医学杂志》2018年第2期142-146,共5页Chinese Journal of Neuromedicine

基　　金：天津市卫生局科技基金（2014KZ100）

摘　　要：目的观察不同剂量伽玛刀照射正常动物三叉神经后三叉神经体感诱发电位（TSEP）的变化特点，以进一步探讨伽玛刀照射剂量与三叉神经受照后变化的关系。方法将15只新西兰兔按随机数字表法分为60Gy照射组、80Gy照射组、100Gy照射组、120Gy照射组及对照组，每组3只。前4组采用Gamma Plan5．34剂量计划系统进行照射靶点设计及剂量规划，照射靶点置于三叉神经脑干进入区，双侧照射，中心剂量分别为60Gy、80Gy、100Gy和120Gy。在照射前及照射后6个月采用神经电检诊仪监测各组实验兔双侧TSEP的潜伏期、峰间潜伏期及波幅，详细记录监测数据并行统计学分析。结果60Gy照射组P1、N1、P2波潜伏期及P1-N1、N1-P2峰间潜伏期以及波幅在照射后6个月与对照组比较差异均无统计学意义（P〉O．05）；80Gy照射组、100Gy照射组、120Gy照射组P1、N1、P2波潜伏期及P1-N1、N1．P2峰间潜伏期以及波幅在照射后6个月与对照组比较差异均有统计学意义（P〈0．05），且随剂量增加变化增大。结论TSEP的变化与伽玛刀照射剂量密切相关，随剂量增加变化增大，其中80Gy为三叉神经产生变化的最低剂量。Objective To explore the relation of gamma knife radiation doses and changes of trigeminal nerves after gamma knife irradiation by studying the changes of trigeminal somatosensory evoked potentials （TSEP） characteristics oftrigeminal nerve roots irradiated by gamma knife in normal animals. Methods Fifteen New Zealand rabbits were divided into 60 Gy irradiation group, 80 Gy irradiation group, 100 Gy irradiation group, 120 Gy irradiation group and control group in accordance with random number table （n=3）. The first 4 groups used Gamma Plan 5.34 planning system to design the radiation targets and radiation doses. The target was placed at trigeminal nerve root entry zone, bilateral irradiation was performed, and the central dose was divided into 60 Gy, 80 Gy, 100 Gy and 120 Gy. The bilateral TSEP was monitored before and 6 months after irradiation. The monitoring data were recorded and statistical analysis was performed. Results P1, N1, P2 wave latencies, P1-N1, N1-P2 interpeak latencies and amplitudes in the 60 Gy irradiation group after irradiation showed no significant differences as compared with those in the control group （P^0.05）; P1, N1, P2 wave latencies, P1-N1, N1-P2 interpeak latencies and amplitudes in the 80 Gy irradiation group, 100 Gy irradiation group, and 120 Gy irradiation group after irradiation showed significant differences as compared with those in the control group （P〈 0.05）, and these changes increase with increase of doses. Conclusion The changes of TSEP, which increase with increase of doses, are closely related to the doses of gamma knife irradiation, of which 80 Gy is the lowest dose to produce changes.

关 键 词：伽玛刀 三叉神经 三叉神经体感诱发电位 

分 类 号：R745.11[医药卫生—神经病学与精神病学]