Spinal Mechanisms of Itch Transmission  

作　　者：Devin M.Barry Admire Munanairi Zhou-Feng Chen 

机构地区：[1]Center for the Study of Itch, Washington University School of Medicine [2]Department of Anesthesiology, Washington University School of Medicine [3]Department of Psychiatry, Washington University School of Medicine [4]Developmental Biology, Washington University School of Medicine

出　　处：《Neuroscience Bulletin》2018年第1期156-164,共9页神经科学通报（英文版）

基　　金：supported by NIH-NIDA T32 Training Grant 5T32DA007261-23;a W.M.Keck Fellowship;supported by NIH Grants 1ROIAR056318-06,R21NS088861-01A1,R01NS094344,R01 DA037261-01A1,and R56AR064294-01A1

摘　　要：Peripheral itch stimuli are transmitted by sensory neurons to the spinal cord dorsal horn, which then transmits the information to the brain. The molecular and cellular mechanisms within the dorsal horn for itch transmission have only been investigated and identified during the past ten years. This review covers the progress that has been made in identifying the peptide families in sensory neurons and the receptor families in dorsal horn neurons as putative itch transmitters, with a focus on gastrin-releasing peptide （GRP）--GRP receptor signaling. Also discussed are the signaling mechanisms, including opioids, by which various types of itch are transmitted and modulated, as well as the many conflicting results arising from recent studies.Peripheral itch stimuli are transmitted by sensory neurons to the spinal cord dorsal horn, which then transmits the information to the brain. The molecular and cellular mechanisms within the dorsal horn for itch transmission have only been investigated and identified during the past ten years. This review covers the progress that has been made in identifying the peptide families in sensory neurons and the receptor families in dorsal horn neurons as putative itch transmitters, with a focus on gastrin-releasing peptide （GRP）--GRP receptor signaling. Also discussed are the signaling mechanisms, including opioids, by which various types of itch are transmitted and modulated, as well as the many conflicting results arising from recent studies.

关 键 词：ITCH NEUROPEPTIDES Spinal cord DRG GPCR signaling 

分 类 号：R338[医药卫生—人体生理学]