围绝经期抑郁症患者文拉法辛治疗前后脑源性神经营养因子的变化  

Changes of BDNF in patients with depression at perimenopausal period after treatment with venlafaxine

作　　者：杨和增[1] 单菲 李敏智[1] 

机构地区：[1]深圳市康宁医院深圳市心理健康实验室,广东深圳518020 [2]深圳市盐田区盐港医院妇产科,广东深圳518083

出　　处：《实用医学杂志》2018年第3期457-459,共3页The Journal of Practical Medicine

基　　金：深圳市盐田区科技创新局科研项目(编号:2012-1-15)

摘　　要：目的探讨女性围绝经期抑郁症患者文拉法辛治疗前后抑郁症状及血清中脑源性神经营养因子(BDNF)水平的变化。方法对40例围绝经期有抑郁症的妇女文拉法辛治疗4周,治疗前后均测评汉密尔顿抑郁量表24项版本(HAMD-24)评分及测定血清BDNF水平,并与40例围绝经期健康妇女比较。结果治疗组抑郁症状有改善(P<0.01);BDNF水平有升高(P<0.01);有效组妇女治疗前后血清BDNF水平均比无效组高(P<0.01),有效组治疗前后BDNF水平有上升(P<0.01)。结论文拉法辛治疗围绝经期抑郁症,BDNF水平提高的同时,抑郁症状明显改善,效果好差与BDNF水平相关。Objective To explore the changes of depressive symptoms and serum level of brain derived neurotrophic factor （BDNF） before and after venlafaxine treatment in female patients with depression. Methods 40 perimenopausal women patients with depression received treatment with venlafaxine for 4 weeks. Before and after treatment, the patients were assessed by the Hamilton Depression Scale （table 24 item version） and serum levels of BDNF were measured. The results were compared with those from 40 healthy menopausal women. Results In the treatment group, the depressive symptoms were improved （P 〈 0.05 ） ; and the BDNF level was elevated （P 〈 0.05）. The serum BDNF levels were higher in the effective group than in the non-effective group （P 〈 0.05 ） ; the BDNF levels were increased （P 〈 0.05） before and after treatment. Conclusions Treatment with venlafaxine for depression in perimenopausal women, BDNF levels are increased and depression symptoms are mproved significantly. The effect is associated with the level of BDNF.

关 键 词：抑郁症 围绝经期 脑源性神经营养因子 抗抑郁药物 

分 类 号：R749.4[医药卫生—神经病学与精神病学]